Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The goal of this clinical trial is to search for biomarkers in tinnitus patients in tinnitus patients and changes in biomarkers before and after treatment. The main questions it aims to answer are:
This study aims to use magnetoencephalography (MEG) to collect the resting state responses before and after treatment in the control group, tinnitus patients in the acoustic stimulation treatment group, and rTMS treatment group. Firstly, compare the differences in power spectrum and brain functional connectivity indicators between tinnitus patients and normal control groups in different frequency bands, providing a theoretical basis for clinical diagnosis, precise positioning of tinnitus damaged areas, and understanding the pathogenesis of tinnitus; Secondly, compare the electrophysiological functional indicators of tinnitus patients before and after treatment to reveal whether the damaged brain network can gradually reshape after treatment, and whether network information can serve as potential biomarkers to indicate the degree of tinnitus recovery; Finally, compare the effectiveness differences between the two treatment methods, analyze their influencing factors, and provide guidance for frequency band precise intervention and rehabilitation of chronic tinnitus patients.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acoustic stimulation therapy | Experimental | Patients in this group will receive acoustic stimulation therapy. |
|
| Repetitive transcranial magnetic stimulation therapy | Experimental | Patients in this group will receive repetitive transcranial magnetic stimulation therapy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acoustic stimulation | Device | The sound used for treatment is selected based on the patient's tinnitus frequency and loudness. Patients receive 90 minutes of acoustic stimulation therapy every day (at least 5 days per week). The entire treatment period is 3 months. |
| Measure | Description | Time Frame |
|---|---|---|
| THI | the scores of tinnitus handicap inventory(0-100) | Baseline |
| THI | the scores of tinnitus handicap inventory(0-100) | within 7 days of treatment completion |
| THI | the scores of tinnitus handicap inventory(0-100) | follow-up for 1 month after treatment completion |
| VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | Baseline |
| VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | within 7 days of treatment completion |
| VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | follow-up for 1 month after treatment completion |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhiwu Huang | Contact | 18964331112 | huangzw086@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhiwu Huang | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D000161 | Acoustic Stimulation |
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D026421 | Sensory Art Therapies |
| D000529 | Complementary Therapies |
| D010812 | Physical Stimulation |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Repetitive transcranial magnetic stimulation | Device | The course of repeated transcranial magnetic stimulation therapy is 4 weeks, with 5, 5, 4, and 3 treatments per week, each lasting 90 minutes (including rest time) |
|
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008919 |
| Investigative Techniques |
| D055909 | Magnetic Field Therapy |