This study is a blinded, prospective, single-center, clinical study conducted in Japanese female subjects between the ages of 20-75 years. This design uses skin biopsy samples from environmentally exposed areas and unexposed (control) areas within the same subjects to assess the gene expression profile from three different age groups.

The primary objective of the skin aging study is to investigate changes in gene expression patterns that occur during the aging process.

Inclusion Criteria:

• Individuals who are willing to read and sign an informed consent form prior to participating in the study.
• Individuals who have a temperature of less than or equal to 100 degrees F at the time of biopsy collection.
• Individuals who had not applied any sunless tanning product on the arms within the past year.
• Individuals with no prior history of alcoholism (or who consume fewer than 2 to 3 alcoholic beverages per day).
• Individuals who have not consumed any anti-aging nutritional supplements (multivitamins and multiminerals are acceptable) or aspirin, NSAIDS, or other pain medication in the last 48 hours before biopsy.

Exclusion Criteria:

• Male gender
• Individuals who did not fit the 'inclusion criteria' above.

Asian female subjects between the ages of 20 to 75 years old who are non-smokers with no history of prior alcoholism.