Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds

Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds

Platelets are a component of blood, which contain factors which can enhance wound healing. This study proposes to evaluate the clinical response of laugh lines treated with a concentrated preparation of the subject's own platelets injected into or under the skin by taking serial photographs of the subject's face over a 12 week period. Also, the same preparation will be injected into or under the skin of the arm near the elbows, and serial biopsies will be taken over a 12 week period.

Inclusion Criteria:

• healthy adults
• aged 25- 75 years
• with moderate to severe nasolabial folds

Exclusion Criteria:

• pregnant
• allergy to local anesthetics
• history of bleeding disorder
• active infection at the treatment site
• injectable filler in the nasolabial folds within past year