Platelet-rich fibrin matrix (PRFM) is made from platelets that are extracted from a patient's blood, and many plastic surgeons and dermatologists have used it to fill in wrinkles and lines on the face. Both patients and doctors have observed that it gives extra volume in these areas and improves overall appearance. However, there is no research that shows how PRFM affects skin quality, such as pores, spots, red areas, and texture. The aim of this study is to determine whether PRFM has a role in rejuvenating facial skin.

Inclusion Criteria:

• Adults 18 years of age and older who had a dermatological concern, specifically, conspicuous spots, pores, rhytids, uneven texture, or red or brown discoloration, and a VISIA complexion analysis score greater than 10
• Agreed to continue any contraceptive hormonal therapy for duration of the study
• Agreed to not initiate the use of hormonal therapy during the study
• Agreed to not undergo any facial procedures or treatments, including injections and fillers, lasers, peels, and topical therapies, during the duration of the study
• Agreed to adhere to a standardized skin care regimen throughout the duration of the study consisting of the use of a single cleanser and moisturizer twice a day
• Agreed to refrain from excessive sun exposure/tanning

Exclusion Criteria:

• History of skin/connective tissue disorders
• History of immunosuppressive therapy or radiotherapy
• Participation in facial procedures, such as injections, lasers, peels, and dermabrasion, in the last six months
• Use of topical/prescription acne medications in the last three months
• Current smokers or prior smokers who quit fewer than 10 years ago