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The aim of the present study is threefold: investigating 1) specific cognitive impairments in patients with congestive heart failure, 2) whether cognitive impairments in patients with decompensated heart failure improve after medical recompensation and 3) whether cognitive functioning is related to the long-term prognosis (mortality, rehospitalisation) of those patients.
The daily routine in clinical settings often shows cognitive impairments in patients with congestive heart failure. Recent studies reported declines in cognitive functioning such as executive functions, episodic memory, perceptual speed and attention. However, less is known regarding the differential impairments of cognitive functioning in patients with decompensated heart failure.
Study objectives:
Study design:
Cognitive functions of patients with decompensated heart (NYHA III-IV) failure are compared to age and gender matched patients with congestive heart failure (NYHA III-IV) without symptoms of cardiac decompensation and with healthy controls. Decompensated patients are tested before and after medical recompensation. For matched patients and controls, the pretest-posttest timing is based on the recompensation time of the respective patient with decompensated heart failure.
The neuropsychological test battery includes measures of episodic memory, working memory, short-term memory, executive functions, perceptual speed and intelligence. In addition, the study applied standardized questionnaires of self assessed quality of life and depression. Relevant physiological data, such as left ventricular systolic function and N-terminal pro brain natriuretic peptide (NT-pro-BNP), are recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| decompensated heart failure patients |
| ||
| chronic heart failure patients | |||
| healthy controls |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| diuretics, inotropica | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| cognitive function in decompensated heart failure patients measured by a cognitive test battery | within 48h of hospitalisation | |
| cognitive function before and after medical recompensation measured by a cognitive test battery | individual time to recompensate | |
| differences in cognitive performance between decompensated heart failure patients, patients with chronic heart failure and healthy controls | 14 months (+/-2 month) |
| Measure | Description | Time Frame |
|---|---|---|
| all cause mortality | 12 month | |
| long-term development of cognitive functioning in patients with heart failure after acute decompensation | 3, 6, 12 and 18 months after acute decompensation |
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Criteria of decompensated heart failure patients
Inclusion Criteria:
Exclusion Criteria:
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university hospital, saarland
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| Name | Affiliation | Role |
|---|---|---|
| Michael Böhm, MD | University Hospital, Saarland | Principal Investigator |
| Ingrid Kindermann, MD | University Hospital, Saarland | Principal Investigator |
| Denise Fischer, Psychologist | University Hospital, Saarland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiology, University of the Saarland | Homburg | Saarland | 66421 | Germany | ||
| Developmental Psychology Unit, Saarland University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22431406 | Result | Kindermann I, Fischer D, Karbach J, Link A, Walenta K, Barth C, Ukena C, Mahfoud F, Kollner V, Kindermann M, Bohm M. Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study. Eur J Heart Fail. 2012 Apr;14(4):404-13. doi: 10.1093/eurjhf/hfs015. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| ID | Term |
|---|---|
| D004232 | Diuretics |
| ID | Term |
|---|---|
| D045283 | Natriuretic Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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Plasma
| Saarbrücken |
| Saarland |
| 66111 |
| Germany |
| D001523 |
| Mental Disorders |