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| Name | Class |
|---|---|
| Deutsche Stiftung für Herzforschung | OTHER |
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The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention. It is assumed that cognitive impairments in patients with congestive heart failure may lead to deficits in medication-adherence and self-care abilities, resulting in increased healthcare costs. Recent studies reported performance improvements after cognitive training that transferred to new, untrained tasks and abilities in healthy subjects across a wide range of ages. This study investigates the effects of cognitive training in patients with congestive heart failure.
Cognitive functions of patients with congestive heart failure (NYHA II-III) before (pretest) and after (posttest) cognitive-training intervention are investigated. Changes in cognitive functions are compared to changes in two control groups: 1) age and gender matched active control group 2) age and gender matched passive waiting list control group.
The neuropsychological test battery applied at pretest and posttest includes measures of episodic memory, working memory, short-term memory, executive functions, perceptual speed and intelligence. In addition, the investigators apply standardized questionnaires of self-assessed quality of life, cognitive functioning in daily life, selfcare, and psychological well-being (depression, anxiety and personality). Relevant physiological data such as ejection fraction, heartrate, N-terminal pro brain natriuretic peptide (NT-pro-BNP) as well as drug blood level are recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | Intervention: Cognitive Training |
|
| Active control group | Active Comparator | Intervention: Test of general knowledge |
|
| Passive control group | No Intervention | No intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive training | Behavioral | Cognitive training on computer. Six sessions with different tasks: "Tiere merken" & "Räumlich visuelles Training" (application BrainTwister) and "Taskswitching" (programmed with eprime) |
| Measure | Description | Time Frame |
|---|---|---|
| Training effects | Improvement in performance in the last trainingssession compared with the performance in the first trainingssession. Performance will be assessed by computesoftware. | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Transfer effects | Transfer effects are measured by comparing cognitive functions in patients with congestive heart failure before and after cognitive training. Cognitive functions will be assessed by different paper-and-pencil tests and computerbased tests. | 5 weeks |
| Changes in quality of life and psychological well-being |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ingrid Kindermann, PD Dr.med. | University Hospital, Saarland | Study Director |
| Julia Karbach, Prof. | Goethe-Universität Frankfurt am Main | Study Director |
| Sonja Wedegärtner, Dipl.Psych. | University Hospital, Saarland | Principal Investigator |
| Maxie Bunz, Dipl.Psych. | University Hospital, Saarland | Principal Investigator |
| Michael Böhm, Prof. | University Hospital, Saarland | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Educational Science, Saarland University | Frankfurt am Main | Hesse | 60323 | Germany | ||
| Clinic for Internal Medicine, Cardioloy, Angioloy, and Internal Intensive Care Medicine, Saarland University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32871668 | Derived | Wedegartner SM, Schwantke I, Kindermann I, Karbach J. Predictors of heart-focused anxiety in patients with stable heart failure. J Affect Disord. 2020 Nov 1;276:380-387. doi: 10.1016/j.jad.2020.06.065. Epub 2020 Jul 15. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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Pre-Test, Intervention, Post-Test, Follow-Up
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Participants were enrolled in Treatment-Group, Waitinglist-Group, or Shamtraining-Group
| Test of general knowledge | Behavioral | Training of general knowledge on computer. Six sessions with different topics. |
|
Changes in quality of life and psychological well-being as the result of cognitive training measured by psychological questionnaires and tests. |
| 5 weeks |
| Long-term benefits of cognitive training in patients with congestive heart failure. | Follow-up assessment by 6 months after training. Long-term benefits will be measured by different paper-and-pencil tests and computerbased tests as well as psychological questionnaires and tests. | 6 month |
| Compliance with medication | Compliance with medication measured as serum level of medication and heart failure-specific self-care duties. | 5 weeks |
| Homburg |
| Saarland |
| 66421 |
| Germany |
| D001523 |
| Mental Disorders |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |