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Cognitive Intervention to Improve Memory in Heart Failure patients
A three arm randomized controlled trial of 276 heart failure patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Computerized Cognitive Training Brain HQ | Experimental | Computerized cognitive training intervention using Brain HQ initiated and continued 1 hour/day, 5 days/week for 8 weeks |
|
| Computerized Crossword Puzzles | Active Comparator | General cognitive stimulation puzzles intervention initiated and continued 1 hour/day, 5 days/week for 8 weeks |
|
| Usual Care | No Intervention | No computerized cognitive intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Computerized Cognitive Training with Brain HQ | Behavioral | Computerized Cognitive Training Brain HQ activities initiated and continued 1 hour/day, 5 days/week for 8 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in delayed recall memory as measured by Hopkins Verbal Learning Test | Change in delayed recall memory as measured by Hopkins Verbal Learning Test | At 8 months |
| Change in serum brain derived neurotrophic factor ( BDNF) Level | Co-Primary Outcome | At 8 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in working memory as measured by CogState One Back Accuracy Task | Change in working memory as measured by CogState One Back Accuracy Task | At 8 months |
| Change in instrumental activities of daily living as measured by Everyday Problems Test |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive Intervention to Improve Memory in Heart Failure Patients - Supplement | Risk of amnestic mild cognitive impairment, Alzheimer disease and related dementias, and memory decline across 36 months | Across 36 months |
Inclusion Criteria:
Exclusion Criteria:
Supplement Eligibility: First 144 patients randomized in the parent trial.
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| Name | Affiliation | Role |
|---|---|---|
| Susan J Pressler, PhD, RN | Indiana University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Indiana University Health | Indianapolis | Indiana | 46202 | United States | ||
| Methodist Hospital-Krannert Institute of Cardiology |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29601367 | Background | Pressler SJ, Giordani B, Titler M, Gradus-Pizlo I, Smith D, Dorsey SG, Gao S, Jung M. Design and Rationale of the Cognitive Intervention to Improve Memory in Heart Failure Patients Study. J Cardiovasc Nurs. 2018 Jul/Aug;33(4):344-355. doi: 10.1097/JCN.0000000000000463. | |
| 35467571 | Background | Algashgari EY, Jung M, Von Ah D, Stewart JC, Pressler SJ. Perceived Facilitators and Barriers to Treatment Fidelity in Computerized Cognitive Training Interventions. J Cardiovasc Nurs. 2022 Apr 20. doi: 10.1097/JCN.0000000000000916. Online ahead of print. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Computerized Crossword Puzzles | Behavioral | Computerized Crossword Puzzles activities initiated and continued 1 hour/day, 5 days/week for 8 weeks |
|
Change in instrumental activities of daily living as measured by Everyday Problems Test
| At 8 months |
| Change in health-related quality of life as measured by Minnesota Living with Heart Failure Questionnaire | Change in health-related quality of life as measured by Minnesota Living with Heart Failure Questionnaire | At 8 months |
| Cost-effectiveness of the Brain HQ training intervention as measured by calculating the Incremental cost effectiveness ratios (ICERs) using medical services costs | Cost-effectiveness of the Brain HQ training intervention as measured by calculating the Incremental cost effectiveness ratios (ICERs) using medical services costs | At 8 months |
| Indianapolis |
| Indiana |
| 46202 |
| United States |
| 32555009 | Background | Halloway S, Jung M, Yeh AY, Liu J, McAdams E, Barley M, Dorsey SG, Pressler SJ. An Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions. Nurs Res. 2020 Sep/Oct;69(5):376-390. doi: 10.1097/NNR.0000000000000454. |
| 34763080 | Result | Pressler SJ, Jung M, Gradus-Pizlo I, Titler MG, Smith DG, Gao S, Lake KR, Burney H, Clark DG, Wierenga KL, Dorsey SG, Giordani B. Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure. J Card Fail. 2022 Apr;28(4):519-530. doi: 10.1016/j.cardfail.2021.10.008. Epub 2021 Nov 8. |
| 36920122 | Derived | Smith AB, Jung M, Pressler SJ, Mocci E, Dorsey SG. Differential Gene Expression Among Patients With Heart Failure Experiencing Pain. Nurs Res. 2023 May-Jun 01;72(3):175-184. doi: 10.1097/NNR.0000000000000648. Epub 2023 Feb 26. |