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The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function. They hypothesize that patients with heart failure have impaired brain perfusion and hemodynamic factors are associated with cognitive dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Controls | Age matched healthy subjects | ||
| Mild DCM | Heart failure patients with dilated cardiomyopathy (DCM) with NYHA-functional class II | ||
| Severe DCM | Heart failure patients with dilated cardiomyopathy (DCM) with NYHA-functional class III/IV |
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| Measure | Description | Time Frame |
|---|---|---|
| Determinants of cerebral impairment | Determinants of cerebral impairment in patients with heart failure compared to controls, where cerebral impairment is defined as decreased cognitive function and cerebral hypoperfusion | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of cognitive impairment | Prevalence of cognitive impairment in patients with heart failure | Baseline |
| Relation of cognitive impairment with local perfusion | Relation of cognitive impairment with perfusion of carotid artery territory and basilar artery territory |
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Inclusion Criteria Control Group:
Exclusion Criteria Control Group:
Inclusion Criteria DCM-group:
Exclusion Criteria DCM-Group:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adriaan A Voors, MD/PhD | Contact | +31 50 3612355 | a.a.voors@umcg.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Centre Groningen | Recruiting | Groningen | Provincie Groningen | 9700 RB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27862767 | Derived | Erkelens CD, van der Wal HH, de Jong BM, Elting JW, Renken R, Gerritsen M, van Laar PJ, van Deursen VM, van der Meer P, van Veldhuisen DJ, Voors AA, Luijckx GJ. Dynamics of cerebral blood flow in patients with mild non-ischaemic heart failure. Eur J Heart Fail. 2017 Feb;19(2):261-268. doi: 10.1002/ejhf.660. Epub 2016 Nov 14. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D002311 | Cardiomyopathy, Dilated |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D006332 | Cardiomegaly |
| D009202 | Cardiomyopathies |
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| Baseline |
| Relation of cognitive impairment with the severity of heart failure | Relation of cognitive impairment with the severity of heart failure | Baseline |
| Relation of cognitive impairment with cardiac output | Relation of cognitive impairment with cardiac output | Baseline |
| Relation of cognitive impairment with the severity of congestion | Relation of cognitive impairment with the severity of congestion | Baseline |
| Relation of cognitive impairment with the decrease in cerebral perfusion | Relation of cognitive impairment with the decrease in cerebral perfusion | Baseline |
| The difference of cognitive domains in above relations | The difference of cognitive domains in above relations | Baseline |
| D000083083 |
| Laminopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |