Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose

Blood Glucose Homeostasis in Type 2 Diabetes: the Effects of Saccharose

Hyperglycemia forms a direct and independent risk factor for the development of cardiovascular co-morbidities in type 2 diabetes. Consumption of sucrose-sweetened soft drinks might further increase the prevalence of hyperglycemic episodes.

The objective of the study was to assess glycemic control in type 2 diabetes patients and healthy lean and obese controls under strict dietary standardization but otherwise free living conditions, with and without the consumption of soft drinks.

Inclusion Criteria:

Lean NGT Group

• Normoglycemic (according to 2006 ADA guidelines)
• BMI < 27 kg/m2

Obese NGT Group

• Normoglycemic
• BMI 30- 35 kg/m2

Obese type 2 diabetes Group

• BMI 30- 35 kg/m2
• Oral blood glucose lowering medication

Exclusion Criteria:

• Exogenous insulin use
• Cardiac disease (any cardiac event in the last 5 years)
• HbA1c >10%
• Microalbuminuria: albumin:creatinine ratio >2,5