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| ID | Type | Description | Link |
|---|---|---|---|
| NJFY0812009 |
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Several factors influence the extension of anesthetic mixture during spinal anesthesia including anesthetic gravity, body position, drug volume, and drug-delivering velocity. However, the effect of temperature of anesthetic mixture on the cephalad sensory blockade is hitherto unknown. The investigators hypothesized that different temperatures of the anesthetic mixture had different velocity of extension after spinal anesthesia. In addition, previous studies suggest that parturients have relative higher sensitivity to temperature. Herein the investigators proposed that the temperature of anesthetic mixture had more extensive effect on the cephalad sensory blockade with spinal anesthesia for cesarean delivery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 20 degree celsius |
|
| 2 | Experimental | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 10 degree celsius |
|
| 3 | Experimental | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 15 degree celsius |
|
| 4 | Experimental | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 25 degree celsius |
|
| 5 | Experimental | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 30 degree celsius |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bupivacaine/fentanyl/morphine | Drug | Hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg |
|
| Measure | Description | Time Frame |
|---|---|---|
| Maximum cephalad sensory blockade to pinprick, cold and touch | From the delivery of anesthetic mixture to 15 min immediate after spinal anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Velocity of the sensory blockade at identical body position | From the delivery of anesthetic mixture to 15 min immediate after spinal anesthesia | |
| The total dose of phenylephrine required to maintain baseline arterial blood pressure | From the delivery of anesthetic mixture to 25 min after spinal anesthesia |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| XiaoFeng Shen, MD | Nanjing Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nanjing Maternal and Child Health Care Hospital | Nanjing | Jiangsu | 210004 | China |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| 6 | Experimental | Mixture of anesthetic including hyperbaric bupivacaine 12 mg, fentanyl 10 microg and morphine 200 microg, with the temperature of 35 degree celsius |
|
| Time interval of the occurrence of the hypotension | From the delivery of the anesthetic mixture to 25 min after spinal anesthesia |
| D000588 |
| Amines |