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Although the exact mechanism remains unknown, the association of pregnancy and decreased local anesthetic requirement is clear. demonstrated that more local anesthetic is required for cesarean section under combined spinal-epidural anesthesia in preterm compared with term patients.
However, in pregnant patients, venous engorgement is prominent in the supine but not the lateral position, which suggests direct compression of the inferior vena cava by the gravid uterus. Second, an increase in intraabdominal pressure may affect the retroperitoneal area and may cause inward movement of soft tissue in the intervertebral foramina. Recent magnetic resonance imaging studies in pregnant patients, although without intraabdominal pressure measurements, suggested the latter because they showed limited contact of engorged veins along the dural sac which may therefore not be responsible for compression of the dura.
If elevated intraabdominal pressure contributes to high anesthetic spread during pregnancy, one would expect a relationship between intraabdominal pressure and maximum sensory block level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intrathecal bupivacaine | Experimental | intrathecal bupivacaine hydrochloride 0.5%,12.5mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine Hydrochloride | Drug | intrathecal bupivacaine will be used for spinal anesthesia in obstetric patients undergoing C-section |
|
| Measure | Description | Time Frame |
|---|---|---|
| sensory level | effect of different parameters in sensory level | from allocation until 24 hours post-operative |
| motor block | effect of different parameters in motor level | from allocation until 24 hours post-operative |
| Measure | Description | Time Frame |
|---|---|---|
| hypotension | incidence of hypotension after spinal anesthesia | from allocation until 24 hours post-operative |
| vasopressor consumption | total dose of ephedrine consumed by the patients |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut governorate | Recruiting | Asyut | Egypt |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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evaluating relationship of sensory level and other patient factors
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| from allocation until 24 hours post-operative |
| D000588 |
| Amines |