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| ID | Type | Description | Link |
|---|---|---|---|
| Cholangiocarcinoma | |||
| Surgery | |||
| Drainage |
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This study is to investigate whether preoperative biliary drainage can reduce the postoperative morbidity in patients with hilar cholangiocarcinoma.
Preoperative biliary drainage(PBD) or not, is a Hot Spot issue in the management of Hilar cholangiocarcinoma. Surgeons from Japan tend to perform PTBD(Percutaneous Transhepatic Biliary Drainage) before a definite operation until the total bilirubin(TB) lower than 85μmol/L. For some patients needed to perform extended curative resection, PVE(Portal Vein Embolization) is performed and thus the duration of PBD may be around six weeks and the final TB is lower than 34μmol/L. Some tend to perform a definite curative operation in a short time after diagnosis. There is no RCT research on the effect of PBD for the resectable Hilar Cholangiocarcinoma patients to date.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preoperative biliary drainage | Experimental |
| |
| Controlled group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preoperative biliary drainage | Procedure | Percutaneous transhepatic biliary drainage(PTBD) is performed under the guidance of ultrasound. The duration may be around four weeks to make the total bilirubin of patients lower than 85μmol/L. |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of postoperative complication | 30 days after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative mortality | 30 days after operation | |
| Overall survival, OS | May, 2013 | |
| Disease free survival, DFS |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lijian Liang | Contact | 86-20-87755766 | 8096 | lianglj@medmail.com.cn |
| Name | Affiliation | Role |
|---|---|---|
| Lijian Liang | Department of hepatobiliary, the first affiliated hospital, Sun Yat-sen University | Study Chair |
| Xiaoyu Yin, MD | Department of Hepatobiliary, the first affiliated hospital, Sun Yat-sen University |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Hepatobiliary, the first affiliated hospital, Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510080 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11573044 | Background | Jarnagin WR, Fong Y, DeMatteo RP, Gonen M, Burke EC, Bodniewicz BS J, Youssef BA M, Klimstra D, Blumgart LH. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 2001 Oct;234(4):507-17; discussion 517-9. doi: 10.1097/00000658-200110000-00010. | |
| 10982608 | Background | Nimura Y, Kamiya J, Kondo S, Nagino M, Uesaka K, Oda K, Sano T, Yamamoto H, Hayakawa N. Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience. J Hepatobiliary Pancreat Surg. 2000;7(2):155-62. doi: 10.1007/s005340050170. |
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| ID | Term |
|---|---|
| D018281 | Cholangiocarcinoma |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
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| May, 2013 |
| D009369 | Neoplasms |