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| ID | Type | Description | Link |
|---|---|---|---|
| achalasia1 |
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Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well.
The objective of the present study is to evaluate tha efficacy of dark chocolate in improving LES relaxation in achalasia patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | dark chocolate consumption during manometry and 2 weeks treatment with dark chocolate |
|
| 2 | Other | placebo comparator: 7 grams of placebo-chocolate at day 1 during manometry, and than crossover to treatment with dark chocolate for 2 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dark chocolate | Dietary Supplement | 21 g/d of dark chocolate for 2 weeks (7 g. before each meal). 7 grams of dark chocolate at day 1 during manometry. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Lower Esophageal Sphincter relaxation before and after dark chocolate consumption. | day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| achalasia symptoms before and during dark-chocolate consumption | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D004931 | Esophageal Achalasia |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| placebo chocolate with crossover to dark chocolate | Dietary Supplement | Placebo at day 1 during manometry, and than crossover to dark chocolate for 2 weeks treatment. |
|
|
| D004066 | Digestive System Diseases |