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| Name | Class |
|---|---|
| University of Aarhus | OTHER |
| University of Oxford | OTHER |
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Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help us to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Sham Comparator | no ischaemia - only sham. Blood pressure cuff inflation up till 10 mmHg on the upper arm for 20 mins. |
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| 2 | Active Comparator | Ischaemia 20 minutes. Blood pressure cuff will be inflated around the upper arm for 20 minutes to induce ischaemia. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Forearm vascular study | Procedure | Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of substance P (2,4,8 pmol/min). Venous blood sampling via cannula in antecubital fossa. |
| Measure | Description | Time Frame |
|---|---|---|
| Net t-PA release from the endothelium after ischaemia reperfusion | Throughout the study |
| Measure | Description | Time Frame |
|---|---|---|
| Change in forearm blood flow after ischaemia reperfusion | throughout the study | |
| Change in platelet-monocyte-binding after ischaemia reperfusion | Throughout the study |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David E Newby, PhD, FRCP | University of Edinburgh | Study Director |
| Rajesh K Kharbanda, PhD, FRCP | University of Oxford | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Edinburgh, 49 Little France Crescent | Edinburgh | EH16 4SB | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21083644 | Derived | Pedersen CM, Cruden NL, Schmidt MR, Lau C, Botker HE, Kharbanda RK, Newby DE. Remote ischemic preconditioning prevents systemic platelet activation associated with ischemia-reperfusion injury in humans. J Thromb Haemost. 2011 Feb;9(2):404-7. doi: 10.1111/j.1538-7836.2010.04142.x. No abstract available. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |