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| ID | Type | Description | Link |
|---|---|---|---|
| DBD0300 | Other Identifier | Biological Sciences |
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The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | Control trial to determine the impact of the ischemic injury on vascular function without intervention | |
| Antioxidant load | Experimental | Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery |
|
| Prostaglandin inhibition | Experimental | Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery |
|
| Combined | Experimental | Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Antioxidant | Dietary Supplement |
| ||
| Prostaglandin inhibitor (Ibuprophen) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in flow mediated dilation | Flow mediated dilation is a measure of vascular function and is measured as the outcome before and after an injury to the inner lining of the artery. | Change from baseline at 15 minutes after ischemia-reperfusion injury |
| Measure | Description | Time Frame |
|---|---|---|
| Change in low flow mediated constriction | low flow mediated constriction is a measure of vascular function and is measured to establish the impact of a vascular injury | Change from baseline at 15 minutes after ischemia-reperfusion injury |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mark Rakobowchuk, PhD | Thompson Rivers University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Essex | Colchester | Essex | CO4 3SQ | United Kingdom |
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| ID | Term |
|---|---|
| D000975 | Antioxidants |
| D011448 | Prostaglandin Antagonists |
| D007052 | Ibuprofen |
| ID | Term |
|---|---|
| D001685 | Biological Factors |
| D045504 | Molecular Mechanisms of Pharmacological Action |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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| Drug |
|
|
| D020011 | Protective Agents |
| D045505 | Physiological Effects of Drugs |
| D020313 | Specialty Uses of Chemicals |
| D006727 | Hormone Antagonists |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010666 | Phenylpropionates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |