The Effect of Ischaemic-Reperfusion and Ischaemic Precond... | NCT00789243

NCT00789243

Protocol Section

Identification Module

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Status Module

Name	Class
University of Aarhus	OTHER
University of Oxford	OTHER

Oversight Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
1	Active Comparator	Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, local ischaemic preconditioning will be induced by inflating a cuff around the non-dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times.	Procedure: Forearm vascular study
2	Active Comparator	Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, remote ischaemic preconditioning will be induced by inflating a cuff around the dominant arm to 200 mmHg for 5 mins followed by 5 mins of reperfusion. This cycle will be repeated 3 times.	Procedure: Forearm vascular study
3	Placebo Comparator	Prior to 20 mins of ischaemia induced by a blood pressure cuff inflated to 200 mmHg around the upper non-dominant arm, sham will be performed by inflating a cuff to 10 mmHg for 5 mins followed by 5 mins of deflation. This cycle will be repeated 3 times.	Procedure: Forearm vascular study

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Forearm vascular study	Procedure	Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of substance P (2,4,8 pmol/min). Venous blood sampling via cannula in antecubital fossa.

Outcomes Module

Measure	Description	Time Frame
Net t-PA release from the endothelium after ischaemia reperfusion and ischaemic preconditioning		Throughout the study

Secondary Outcomes

Measure	Description	Time Frame
Change in forearm blood flow after ischaemia reperfusion and ischaemic preconditioning		throughout the study
Change in platelet-monocyte-binding after ischaemia reperfusion and ischaemic preconditioning		Throughout the study

Eligibility Module

Contacts/Locations Module

Name	Affiliation	Role
David E Newby, PhD, FRCP	University of Edinburgh	Study Director
Rajesh K Kharbanda, PhD, FRCP	University of Oxford	Study Director

Facility	Status	City	State	ZIP	Country	Contacts
University of Edinburgh, 49 Little France Crescent		Edinburgh		EH16 4SB	United Kingdom

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
21990263	Derived	Pedersen CM, Barnes G, Schmidt MR, Botker HE, Kharbanda RK, Newby DE, Cruden NL. Ischaemia-reperfusion injury impairs tissue plasminogen activator release in man. Eur Heart J. 2012 Aug;33(15):1920-7. doi: 10.1093/eurheartj/ehr380. Epub 2011 Oct 11.
21083644	Derived	Pedersen CM, Cruden NL, Schmidt MR, Lau C, Botker HE, Kharbanda RK, Newby DE. Remote ischemic preconditioning prevents systemic platelet activation associated with ischemia-reperfusion injury in humans. J Thromb Haemost. 2011 Feb;9(2):404-7. doi: 10.1111/j.1538-7836.2010.04142.x. No abstract available.

Condition Browse Module