Peripheral Metabolic Effects of Ghrelin

Peripheral Metabolic Effects of Intra Arterial Ghrelin Infusion in Healthy Controls

The aim of this study is to investigate putative peripheral effects of ghrelin on glucose and lipid metabolism in healthy men. Eight subjects will be enrolled. The hypothesis is that ghrelin infusion causes insulin resistance and lipolysis.

Inclusion Criteria:

1. BMI < 27 kg/m2
2. Written informed consent
3. Non-smoker

Exclusion Criteria:

1. Any disease including epilepsy
2. Any use of medications (excl. paracetamol)
3. Present or previous malignancy
4. Alcohol dependency
5. Allergy to any trial medication