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The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ghrelin | Active Comparator | Ghrelin |
|
| Placebo | Placebo Comparator | Ringer acetate is used for placebo. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acyl ghrelin | Drug | Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Interstitial concentrations of glycerol | Interstitial concentrations of glycerol at t=120 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Interstitial concentrations of lactate | Interstitial concentrations of lactate at t=120 minutes | |
| Interstitial concentrations of glucose | Interstitial concentrations of glucose at t=120 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Esben T. Vestergaard, MD PhD | University of Aarhus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University Hospital | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23592479 | Derived | Vestergaard ET, Moller N, Jorgensen JO. Acute peripheral tissue effects of ghrelin on interstitial levels of glucose, glycerol, and lactate: a microdialysis study in healthy human subjects. Am J Physiol Endocrinol Metab. 2013 Jun 15;304(12):E1273-80. doi: 10.1152/ajpendo.00662.2012. Epub 2013 Apr 16. |
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| ID | Term |
|---|---|
| C000710987 | acyl-ghrelin |
| D054439 | Ghrelin |
| ID | Term |
|---|---|
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
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| Placebo (Ringer acetate) | Drug | Ringer acetate 2 microliter/min for 300 minutes |
|
| D000602 | Amino Acids, Peptides, and Proteins |