Ghrelin Decreases Insulin Sensitivity

Intravenous Ghrelin Infusion Decreases Insulin Sensitivity in Healthy Young Men

Ghrelin administration increases appetite and, in rodents, induces weight gain. The aim of this study is to investigate the effect of short term ghrelin administration to humans on metabolism.

The current study is initiated in order to assess the impact of acute ghrelin administration on insulin resistance measured by a hyperinsulinemic euglycemic clamp. Second, as free fatty acid is the predominant substrate during fasting, we aim to asses the effects of ghrelin on local and systemic lipolysis.

Inclusion Criteria:

• healthy men, age >= 18 yr age < 50 yr, body mass index < 27.5 kg/m2above or equal to 18 yr

Exclusion Criteria:

• any disease, use of prescribed medication, age < 18 yr or >= 50 yr