Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Lung Transplantation (Ergo-LTx)

Prospective Intervention Study to Improve HRQoL and Exercise Tolerance After Lnug Transplantation

A prospective, interventional rehabilitation program was initiated to improve exercise capacity and psychosocial functioning in patients after lung transplantation (LTx) and to evaluate long-term effects on health-related quality of life (HRQoL).

Study subjects were randomized to either intervention or to control group and were followed with regular cardiopulmonary exercise testings and HRQoL measurements (SF-36) for 36±3 months after LTx. Patient characteristics did not differ concerning age, gender, and diagnosis at study entry. IG patients received regular psychosocial support and performed a home-based supervised ergometer training program. CG patients were recommended to perform regular exercising.

Inclusion Criteria:

• Lung transplant (single, double, combined heart-lung) (6-9 mts post Tx)
• Stable health condition at study entry (pt stays within home environment)
• Age ≥ 18 yrs
• Sufficient language skills to answer questionnaire
• Follow-up at our center
• Willingness to participate by written informed consent

Exclusion Criteria:

• BOS III diagnosis before study inclusion
• Episodes of recurrent acute rejections
• Medical contra-indication for regular exercise ergometer training
• Malignancy
• Multi-resistent pathogens