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The purpose of this study is to explore the possible cognitive effects of oxybutynin tablets and oxybutynin gel.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | oral oxybutynin |
|
| 2 | Experimental | oxybutynin topical gel |
|
| 3 | Placebo Comparator | placebo tablets plus placebo gel |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| oxybutynin chloride immediate-release | Drug | capsule containing oxybutynin chloride immediate-release 5 mg tablet administered three times daily, and placebo gel administered once daily |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of accuracy of delayed recall name-phase association test | one week |
| Measure | Description | Time Frame |
|---|---|---|
| Effects on other cognitive domains measured by various tests | one week |
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Inclusion Criteria:
Exclusion Criteria:
Other protocol-defined inclusion/exclusion criteria may apply
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tucson | Arizona | 85741-3656 | United States | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22909146 | Derived | Kay GG, Staskin DR, MacDiarmid S, McIlwain M, Dahl NV. Cognitive effects of oxybutynin chloride topical gel in older healthy subjects: a 1-week, randomized, double-blind, placebo- and active-controlled study. Clin Drug Investig. 2012 Oct 1;32(10):707-14. doi: 10.1007/BF03261924. |
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| oxybutynin chloride topical gel | Drug | oxybutynin chloride topical gel applied once daily, and capsule containing placebo tablet administered three times daily |
|
| placebo | Other | capsule containing placebo tablet administered three times daily, and placebo gel administered once daily |
|
| National City |
| California |
| 91950 |
| United States |
| Maitland | Florida | 32751 | United States |
| Naples | Florida | 34102 | United States |
| Ocala | Florida | 34471 | United States |
| Atlanta | Georgia | 30341-4155 | United States |