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Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers
Double Blind, cross-over, randomized and controlled versus placebo, study in healthy volunteers.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rimonabant and Paracetamol and placebo | Drug | evaluation of an possible inhibiting effect of rimonabant on the analgesic effect of paracetamol in healthy volunteers |
| Measure | Description | Time Frame |
|---|---|---|
| Pain's threshold with electrical stimulation (Pain Matcher). Pain's threshold with mechanical stimulation (electronical Von Frey). | during electrical stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Plasmatic concentration of paracetamol or his metabolite with or without Rimonabant | with or without rimonabant |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dubray Claude, Pr | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CIC-CPC | Clermont-Ferrand | 63000 | France | |||
| CHU Clermont-Ferrand |
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| ID | Term |
|---|---|
| D010146 | Pain |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010468 | Perceptual Disorders |
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| ID | Term |
|---|---|
| D000077285 | Rimonabant |
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D011720 | Pyrazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Clermont-Ferrand |
| 63003 |
| France |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |
| D010880 |
| Piperidines |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |