Antagonistic Interaction CB1-paracetamol

Evaluation of the Interaction of Rimonabant (Antagonist of CB1 Receptor) on the Analgesic Effect of Paracetamol in Intravenous Administration

Evaluation of an possible inhibiting effect of Rimonabant on the analgesic effect of Paracetamol in healthy volunteers

Double Blind, cross-over, randomized and controlled versus placebo, study in healthy volunteers.

Inclusion Criteria:

• Healthy volunteers
• between 18 and 40 years old
• written consent given

Exclusion Criteria:

• Rimonabant or paracetamol hypersensibility
• Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
• Concomitant medication
• Chronical diseases