Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers

Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers

The aim of this study is to check if Naloxone induce an inhibiting effect on the analgesic effect of paracetamol in healthy volunteer, using evoked potentials.

Double Blind, cross-over study in healthy volunteers.

Inclusion Criteria:

• Healthy men
• between 18 and 40 years old
• written consent given

Exclusion Criteria:

• Naloxone or paracetamol hypersensibility
• Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
• Concomitant medication