Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol

A previous study has shown that tropisetron inhibits the analgesic effect of paracetamol in healthy volunteers. This study aims at confirming this pharmacodynamic interaction in patients with post-surgery pain.

The study is a comparison of the analgesic action of paracetamol versus tropisetron + paracetamol in 30 patients who had surgery of the ear. The evaluation criteria will be the score on the visual analogue scale for pain evaluation.

Inclusion Criteria:

• More than 18 years
• Men or women
• Ear surgery
• Written consent given

Exclusion Criteria:

• Paracetamol hypersensibility
• Tropisetron hypersensibility