Infections due to influenza and pneumococcus can be very serious and cause death. Anyone can get these infections. However, some people are at greater risk from the disease, including people 65 and older, the very young, and people with special health problems such as people with certain types of cancer, heart, lung, or kidney disease, or diabetes. Influenza can cause a very serious lung infection (pneumonia) and increase the risk of stroke and heart attacks. Pneumococcal disease can lead to serious infections in the lungs (pneumonia), the blood (bacteremia), and the covering of the brain (meningitis). People with the special health problems mentioned above are even more likely to die from the disease. Although there are drugs to treat these infections, they are not always effective. This makes prevention of the disease through vaccination even more important.

This study will look at the body's response to influenza and pneumococcal vaccination. We want to see how well they it will protect. Immunization is the same as vaccination. Our goal is to protect as much as we can. We are doing the study because more information is needed to see how well older patients with cancer respond to these vaccines and how well they protect against disease caused by influenza and pneumococcus.

Inclusion Criteria:

• Patient must be > or = to 65 years of age.
• Patient may be an in patient or an out-patient.
• Patient must have a diagnosis of prostate, lung, or breast cancer.
• Patient must have a life expectancy of > or = to 6 months.
• Patient must have a Karnofsky score of >40%
• Patient must be willing to return to the hospital in 8-12 weeks following immunization for blood work.
• Patients must have a platelet count of >75,000 for intramuscular injection.
• Patient may be of either gender and of any ethnic background.
• Patients must be able to understand the nature and risk of the proposed study and be able to sign consent.

Volunteer eligibility:

• MSKCC employee
• Age > or = to 65 years of age
• No previous diagnosis of cancer except basal cell carcinoma, resected Stage I melanoma or in situ cervical carcinoma. Volunteers may have had a prior history of other cancers > 3 years which required only local resection, local radiation and/or hormonal therapy such as androgen blockade.
• Patients must be able to understand the nature and risk of the proposed study and be able to sign consent.

Exclusion Criteria:

• Karnofsky score <40%:
• Patients who have received an autologous or allogeneic HCT
• Active uncontrolled bacterial or fungal infection
• Hypersensitivity to egg protein (eggs or egg products), chicken proteins, or any component in the influenza vaccine
• Prior history of any life-threatening reaction after previous administration of any influenza vaccine or any component such as thimerosal (inclusion of thimerosal varies among packaging)
• Latex allergy if going to receive the influenza vaccine
• On-going neurologic disorder (mental status change, uncontrolled seizures, encephalopathy)
• Treatment or planned treatment with cyclophosphamide, ifosphamide, or > or = to 1 mg/kg prednisone or its equivalent 12 weeks within 12 weeks of vaccination.
• HIV-1,2 seropositive patients.
• Patients not signing informed consent.
• Patients receiving the seasonal influenza vaccine may not have had it within 6 months of enrollment

Healthy controls exclusion:

• Volunteers ineligible to receive either vaccine
• Volunteers unwilling or unable to sign consent
• Hypersensitivity to egg protein (eggs or egg products), chicken proteins, or any component in the influenza vaccine
• Latex allergy