Influenza vaccination is indicated for all adults, but the immunogenicity of vaccination has not been assessed in all situations. We are conducting a prospective unblinded study of influenza vaccine recipients.

Influenza vaccination is indicated for all adults, but the immunogenicity of vaccination has not been assessed in all situations. In particular, immune responses following influenza vaccination have not been studied in the setting of advanced melanoma and in the context of various anti-tumor treatments. In this study, we will look at the immune response of subjects receiving vaccination.

Inclusion Criteria:

• adults capable of providing consent
• have a diagnosis of locally advanced or metastatic melanoma

Exclusion Criteria:

• are allergic to influenza vaccination
• have received influenza vaccination within the past 6 months
• require prednisone, methotrexate, or other immunosuppressing medications
• have HIV infection
• have a history of solid organ or bone marrow transplant
• require combination immunotherapy
• are on other studies requiring blood draws that might exceed 450 mL total during the period of the influenza vaccine study