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This study will look at your body's response to the new immunizations. We want to see how well they will protect you. Immunization is the same as vaccination. Our goal is to protect you as much as we can. We do not want you to have the measles, mumps, or whooping cough. We are doing the study because there is no standard way to re-immunize people after cancer treatments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Other | Immunization Schedule patients <7 years. |
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| B | Other | Immunization Schedule patients > or = to 7 years and <11 years of age |
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| C | Other | Immunization Schedule patients > or = to 11 years of age |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immunization Schedule patients <7 years. | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| To prospectively determine the response rate and duration of protective titers following revaccination with routine childhood immunizations in pediatric survivors of childhood cancer. | conclusion of study |
| Measure | Description | Time Frame |
|---|---|---|
| To determine whether in vitro parameters of lymphoid reconstitution correlate with response and duration of response. | conclusion of study |
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Inclusion Criteria:
Patient must be < or less 18 years of age at cancer diagnosis
Patient must be 3 to 24months following completion of chemotherapy for malignant disease.
i. For patients with leukemia: bone marrow aspirate defined as <5% blasts, absence of cytogenetic abnormality by FISH or karyotype (if applicable) and no evidence of CSF involvement (if applicable) ii. For patients with solid tumors remission will be determined by appropriate radiologic scans, and other tests, including bone marrow aspirate and biopsies demonstrating absence of extrinsic cells and absence of specific FISH or cytogenetic abnormality (if applicable), iii. For patients with lymphoma, remission will be determined by bone marrow aspirate and biopsy, radiologic scans and other tests. Bone marrow will show <5% blasts, absence of cytogenetic abnormality by FISH or karyotype (if applicable), and flow cytometry (if lymphoma specific marker present) and absence of CNS disease by spinal fluid (if applicable)
Patient may be of either gender and of any ethnic background
Patients or their guardians must be able to understand the nature and risk of the proposed study and be able to sign consent.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nancy Kernan, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan-Kettering Cancer Center | New York | New York | 10021 | United States |
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| Label | URL |
|---|---|
| Memorial Sloan-Kettering Cancer Center | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jun 3, 2026 | |
| Reset | Jun 26, 2026 |
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| Immunization Schedule patients > or = to 7 years and <11 years of age | Biological |
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| Immunization Schedule patients > or = to 11 years of age | Biological |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jun 3, 2026 | Jun 26, 2026 | |||
| Jul 1, 2026 |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D014612 | Vaccines |
| C538862 | 13-valent pneumococcal vaccine |
| D022542 | Measles-Mumps-Rubella Vaccine |
| D019433 | Chickenpox Vaccine |
| D000375 | Aging |
| ID | Term |
|---|---|
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D017778 | Vaccines, Combined |
| D008458 | Measles Vaccine |
| D014765 | Viral Vaccines |
| D009108 | Mumps Vaccine |
| D012411 | Rubella Vaccine |
| D022283 | Herpesvirus Vaccines |
| D048788 | Growth and Development |
| D010829 | Physiological Phenomena |
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