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| Name | Class |
|---|---|
| Bayer | INDUSTRY |
| Kuopio University Hospital | OTHER |
| Tampere University | OTHER |
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In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.
Low-dose acetylsalicylic acid irreversibly inhibits the cyclo-oxygenase enzyme in platelets, thus preventing the synthesis of thromboxane, which causes vasoconstriction and platelet aggregation. By this mechanism low-dose aspirin may enhance ovarian and uterine blood flow and tissue perfusion and thus improve ovarian responsiveness for gonadotrophins and endometrial receptivity for implantation. Randomized controlled studies and meta-analyses on the low-dose aspirin therapy to improve IVF/ICSI outcome or uterine hemodynamics have revealed conflicting results.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Acetylsalicylic acid 100 mg daily perorally |
|
| 2 | Placebo Comparator | Placebo daily perorally |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acetylsalicylic acid | Drug | Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection |
| Measure | Description | Time Frame |
|---|---|---|
| Pregnancy rate | Five weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| Uterine artery and spiral artery pulsatility index values | On the day of embryo transfer |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mervi Haapsamo, MD | University Hospital of Oulu, Finland | Principal Investigator |
| Juha Rasanen, MD | University Hospital of Oulu, Finland and Oregon Health Sciences University, Oregon USA | Study Director |
| Hannu Martikainen, MD | University Hospital of Oulu, Finland | Study Director |
| Juha S Tapanainen, Prof | University Hospital of Oulu, Finland | Study Director |
| Seppo Heinonen, Prof | University Hospital of Kuopio, Finland | Study Director |
| Helena Tinkanen, MD | Unversity Hospital of Tampere, Finland | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Oulu, Department of Obstetrics and Gynecology | Oulu | 90220 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20943705 | Derived | Haapsamo M, Martikainen H, Tinkanen H, Heinonen S, Nuojua-Huttunen S, Rasanen J. Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study. Hum Reprod. 2010 Dec;25(12):2972-7. doi: 10.1093/humrep/deq286. Epub 2010 Oct 13. | |
| 19153091 |
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|
| Placebo | Drug | Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection |
|
| Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin and uterine haemodynamics on the day of embryo transfer in women undergoing IVF/ICSI: a randomized, placebo-controlled, double-blind study. Hum Reprod. 2009 Apr;24(4):861-6. doi: 10.1093/humrep/den489. Epub 2009 Jan 18. |
| ID | Term |
|---|---|
| D011271 | Pregnancy, Ectopic |
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D046110 | Hypertension, Pregnancy-Induced |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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