It is the aim of the multi-centric and prospective registry to analyze in patients with CAD the impact of different grades of renal failure on the outcome and course of the patients and to correlate these with clinical variables.

In particular, the registry has the following objectives:

• prospective consecutive assessment of all patients with coronary artery disease and renal failure in the participating hospitals of the registry
• evaluation of the outcome and course of patients with regard to their different stages of renal failure at baseline
• analysis of the impact of different therapeutic strategies on acute and long-term outcomes
• identification of clinical risk factors, novel biomarkers and genetic markers for an unfavorable long-term outcome

Inclusion Criteria:

• Women and men >= 18 years of age
• Patients with actually performed interventional coronary angiography and there a documented coronary heart disease, defined as at least one documented stenosis >= 50 % in at least one main coronary vessel (Main steam; RCX; RIVA; RCA)
• European/Caucasian descent (European/Caucasian parents and grandparents)
• Availability of an urine, serum- and EDTA blood sample of the patient
• Documented consent of patients for handling of personal medical data, including a genetic analysis

Exclusion Criteria:

• Patients who have been already recruited into this registry
• Patients with organ transplantations, apart from kidney transplantations
• Immunosuppressive therapy, apart from immunosuppressive therapy after kidney transplantation
• Patients with polycystic renal disease
• Pregnant and breastfeeding patients
• Known malignant tumor

Patients with diagnosed coronary artery disease were consecutively enrolled and classified into six groups according to their kidney function