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| Name | Class |
|---|---|
| Aerospace Center Hospital | OTHER |
| Beijing Chao Yang Hospital | OTHER |
| Cangzhou Central Hospital of Tianjin Medical University | UNKNOWN |
| Civil Aviation General Hospital |
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Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special patient population in China. As a nationwide, observational, multicenter cohort study, this study consecutively included ESRD patients on dialysis with significant CAD at 30 tertiary care centers in 12 provinces in China from January 2015 to June 2021. Patient data collected included demographics, comorbidities, cardiac history, cardiac function, location and severity of CAD, procedural information, medications, and clinical events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CAD | The investigators recruited all consecutive end-stage renal disease patients requiring dialysis who had significant coronary artery disease, defined as 50% or greater stenosis in any of three main coronary arteries or left main coronary artery on visual assessment of the coronary angiogram |
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause death | All-cause deaths include cardiovascular death and non-cardiovascular death. Cardiovascular death is defined as death due to acute myocardial infarction, heart failure, sudden cardiac death, stroke, cardiovascular procedure, or cardiovascular hemorrhage. Non-cardiovascular death: any death not covered by the above definitions, such as death caused by infection, malignancy, sepsis, pulmonary causes, accident, suicide, or trauma. | 12-month follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular events | A composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. | From the hospital admission to 12-month follow-up |
| Major or clinically relevant nonmajor bleeding |
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Inclusion Criteria:
Exclusion Criteria:
-
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The population of this study will be selected from January 2015 to June 2021 among 30 tertiary medical centers across 12 provinces in China
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| Name | Affiliation | Role |
|---|---|---|
| Jingang Zheng, MD, PhD | China-Japan Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China-Japan Friendship Hospital | Beijing | Beijing Municipality | 100029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42110186 | Derived | Zhao X, Xie E, Zhai Z, Sun D, Shen S, He H, Liu W, Cai L, Zeng H, Zheng J. A New and Robust Prognostic Biomarker for Mortality Risk Prediction in Dialysis Patients With Coronary Artery Disease: Red Cell Distribution Width-to-Albumin Ratio. Rev Cardiovasc Med. 2026 Apr 20;27(4):47939. doi: 10.31083/RCM47939. eCollection 2026 Apr. | |
| 40493132 |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D007676 | Kidney Failure, Chronic |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| OTHER |
| Dongguan Tungwah Hospital | OTHER |
| Emergency General Hospital | OTHER |
| Fifth Affiliated Hospital of Xinjiang Medical University | OTHER |
| First Central Hospital of Tianjin | UNKNOWN |
| Fuwai Yunnan Cardiovascular Hospital | OTHER |
| Guangdong Provincial People's Hospital | OTHER |
| Henan Provincial Chest Hospital | OTHER |
| Ningbo No. 1 Hospital | OTHER |
| Peking University People's Hospital | OTHER |
| Peking University Shougang Hospital | OTHER |
| People's Hospital of Xinjiang Uygur Autonomous Region | OTHER |
| Tianjin Medical University Second Hospital | OTHER |
| Shaoxing People's Hospital | OTHER |
| Shengjing Hospital | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| the First Affiliated Hospital, Harbin Medical University | UNKNOWN |
| Zhejiang University | OTHER |
| People's Hospital of Guangxi Zhuang Autonomous Region | OTHER |
| The Third People's Hospital of Chengdu | OTHER |
| Tianjin Medical University General Hospital | OTHER |
| Tianjin Union Medicine Center | UNKNOWN |
| Tongji Hospital | OTHER |
| West China Hospital | OTHER |
| Xuanwu Hospital, Beijing | OTHER |
| Wuhan University | OTHER |
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A bleeding event meeting Bleeding Academic Research Consortium criteria type 2, 3, or 5.
| From the hospital admission to 12-month follow-up |
| Cardiovascular death | Cardiovascular death is defined as death due to acute myocardial infarction, heart failure, sudden cardiac death, stroke, cardiovascular procedure, or cardiovascular hemorrhage. | From the hospital admission to 12-month follow-up |
| Non-fatal myocardial infarction | Non-fatal myocardial infarction is confirmed in patients with ischemic symptoms, elevated serum cardiac biomarkers and/or distinctive ECG changes. | From the hospital admission to 12-month follow-up |
| Non-fatal myocardial stroke | Non-fatal myocardial stroke is confirmed as a new neurological deficit attributed to a vascular cause in the central nervous system with imaging evidence by computed tomography or magnetic resonance imaging. | From the hospital admission to 12-month follow-up |
| Major bleeding | A bleeding event meeting Bleeding Academic Research Consortium criteria type 3, or 5. | From the hospital admission to 12-month follow-up |
| Clinically relevant nonmajor bleeding | A bleeding event meeting Bleeding Academic Research Consortium criteria type 2. | From the hospital admission to 12-month follow-up |
| Follow-up major adverse cardiovascular and clinical events | We will follow up the patients by telephone and outpatient service to know the all-cause mortality (cardiovascular and non-cardiovascular) and cardiovascular events. | From the hospital admission, and up to 10 years |
| Li Y, Xie E, Chen Q, Gao Y, Meng Z, Yu C, Yang Y, Sheng Z, Fu C, Du L, Pang W, Chen M, Zheng J. Effects of Angiotensin-Converting Enzyme Inhibitors/Angiotensin II Receptor Blockers on Prognosis in Acute Coronary Syndrome Patients with Preserved Ejection Fraction Undergoing Regular Dialysis. Cardiovasc Drugs Ther. 2026 Apr;40(2):589-598. doi: 10.1007/s10557-025-07720-2. Epub 2025 Jun 10. |
| 39317971 | Derived | Xie E, Wu Y, Ye Z, He Y, Zeng H, Luo J, Chen M, Pang W, Xu Y, Gao C, Guo X, Cai L, Ji Q, Yang Y, Wu D, Yuan Y, Wan J, Ma Y, Zhang J, Du Z, Yang Q, Cheng J, Ding C, Ma X, Yin C, Fan Z, Tang Q, Li Y, Sun L, Lu C, Chi J, Yao Z, Gao Y, Yu C, Ren J, Zheng J. Percutaneous coronary intervention vs . medical therapy in patients on dialysis with coronary artery disease in China. Chin Med J (Engl). 2025 Feb 5;138(3):301-310. doi: 10.1097/CM9.0000000000003295. Epub 2024 Sep 25. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |