Efficacy of Vitamin C Injection on Fatigue in Workers After Work

Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.

Inclusion Criteria:

• Company workers working at least 5 days a week from morning to evening
• Volunteers who provided written informed consent

Exclusion Criteria:

• Acute illness
• Chronic disease such as diabetes, hypertension, liver disease, or renal disease
• Previous history of renal stone or gout
• Pregnant or lactating women
• Hypersensitivity to vitamins or intravenous injections
• History of vitamin supplements orally or parenterally within 2 days