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| ID | Type | Description | Link |
|---|---|---|---|
| K56721 |
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We wanted to find out if the early use of antipyretics is capable in preventing recurrences of febrile seizures. When a child has had his/her first febrile seizure, the parents were instructed to give him/her antipyretic medication every time when the child had a new episode of fever during two years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 drug | Active Comparator | diclofenac 15 mg/kg suppository once |
|
| 2 drug | Placebo Comparator | Placebo suppository once |
|
| 3 drug | Active Comparator | acetaminophen mixture 15 mg/kg up to four times a day |
|
| 4 drug | Active Comparator | ibuprofen mixture 10 mg/kg up to four times a day |
|
| 5 drug | Placebo Comparator | oral placebo mixture up to four times a day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diclofenac, Paracetamol, Ibuprofen | Drug | Immediately if temperature > 38 degree Celsius, diclofenac suppository 1,5 mg/kg once or placebo suppository After eight hours, if temperature still < 38 degree Celsius, acetaminophen mixture 15 mg/kg up to four times a day, or ibuprofen mixture 10 mg/kg up to four times a day, or placebo mixture up to four times a day as long as temperature < 38 degree Celsius |
| Measure | Description | Time Frame |
|---|---|---|
| recurrence of febrile seizure | two years |
| Measure | Description | Time Frame |
|---|---|---|
| we only had the primary outcome measure | two years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Heikki Rantala, Professor | University of Oulu | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heikki Rantala | Oulu | 90014 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19736332 | Derived | Strengell T, Uhari M, Tarkka R, Uusimaa J, Alen R, Lautala P, Rantala H. Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial. Arch Pediatr Adolesc Med. 2009 Sep;163(9):799-804. doi: 10.1001/archpediatrics.2009.137. |
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| ID | Term |
|---|---|
| D004008 | Diclofenac |
| D000082 | Acetaminophen |
| D007052 | Ibuprofen |
| ID | Term |
|---|---|
| D010648 | Phenylacetates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| D000083 |
| Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D010666 | Phenylpropionates |