Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients

Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol

The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.

To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study

Inclusion Criteria:

• Migraine without aura
• Weight 50-100 kg

Exclusion Criteria:

• Other significant diseases
• Migraine 5 days prior to experiment