A Study of MCI-196 in Chronic Kidney Disease Stage V Subj... | NCT00542815

NCT00542815

Status Module

Oversight Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Label	Type	Description	Intervention Names
1	Experimental		Drug: MCI-196
2	Active Comparator		Drug: Another Phosphate binder (Sevelamer)

Name	Type	Description	Arm Group Labels	Other Names
MCI-196	Drug	3g to 15g/day (3 times a day), Tablet, 40 weeks of flexible dose	1

Outcomes Module

Measure	Description	Time Frame
The Change in Serum Phosphorus for MCI-196 and Sevelamer	Change from Baseline to Week 52 (LOCF)	52 weeks (Baseline-52 weeks)

Measure	Description	Time Frame
The Percent Change in Serum LDL-cholesterol for MCI-196 and Sevelamer	Percent Change from Baseline to Week 52 (LOCF)	52 weeks (Baseline-52 weeks)

Eligibility Module

Name	Affiliation	Role
Professor	Information at Mitsubishi Pharma Europe	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
40576086	Derived	Natale P, Green SC, Ruospo M, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2025 Jun 27;6(6):CD006023. doi: 10.1002/14651858.CD006023.pub4.

Results Section

Participant Flow Module

ID	Title	Description
FG000	MCI-196 From E07 / E08 Studies	3, 6, 9, 12, or 15g / day as titrated
FG001	MCI-196 From E07 Study	3, 6, 9, 12, or 15g / day as titrated

Baseline Characteristics Module

Outcome Measures Module

Adverse Events Module

More Info Module

Arm/Group Information

ID	Title	Description
BG000	MCI-196 From E07 / E08 Studies	3, 6, 9, 12, or 15g / day as titrated
BG001	MCI-196 From E07 Study	3, 6, 9, 12, or 15g / day as titrated
BG002	Sevelamer From E07 Study	2.4, 4.8, 7.2, 9.6, or 12.0g / day as titrated
BG003	Total	Total of all reporting groups

Baseline Measures

Title

Description

Population Description

Parameter Type

Dispersion Type

Unit of Measure

Calculate Percentage

Denominator Units Selected

Denominators

Classes

Age, Customized

Number

participants

Title

Denominators

Categories

Title	Measurements
	OG000-1.23± 1.78 OG001-1.47± 1.68 OG002-2.26± 1.82

Secondary

The Percent Change in Serum LDL-cholesterol for MCI-196 and Sevelamer

Percent Change from Baseline to Week 52 (LOCF)

Posted

Mean

Standard Deviation

percentage change of LDL-cholesterol

52 weeks (Baseline-52 weeks)

ID	Title	Description
OG000	MCI-196 From E07 / E08 Studies	3, 6, 9, 12, or 15g / day as titrated
OG001	MCI-196 From E07 Study	3, 6, 9, 12, or 15g / day as titrated
OG002	Sevelamer From E07 Study	2.4, 4.8, 7.2, 9.6, or 12.0g / day as titrated

Units	Counts
Participants

Arm/Groups

ID	Title	Description	Serious Events (Affected)	Serious Events (At Risk)	Other Events (Affected)	Other Events (At Risk)
EG000	MCI-196 From E07/E08 Studies	3, 6, 9, 12, or 15g / day as titrated	74	432	310	432
EG001	MCI-196 From E07 Study	3, 6, 9, 12, or 15g / day as titrated	31	76	75	76
EG002	Sevelamer From E07 Study	2.4, 4.8, 7.2, 9.6, or 12.0g / day as titrated	48	124	112	124

Serious Adverse Events

Term	Organ System	Statistical Information
Anaemia	Blood and lymphatic system disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Acute coronary syndrome	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Acute myocardial infarction	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Angina pectoris	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Angina unstable	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Atrial fibrillation	Cardiac disorders	EG0005 affected432 at risk EG0013 affected76 at risk EG0020 affected124 at risk
Atrioventricular block	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Atrioventricular block complete	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Bundle branch block left	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Cardiac arrest	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Cardiac failure	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Cardiac failure acute	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Cardiac failure congestive	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Cardio-respiratory arrest	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Cardiopulmonary failure	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Cardiovascular insufficiency	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Congestive cardiomyopathy	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Coronary artery disease	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Coronary artery insufficiency	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Coronary artery stenosis	Cardiac disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Ischaemic cardiomyopathy	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Myocardial infarction	Cardiac disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Myocardial ischaemia	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Pericarditis	Cardiac disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Ventricular fibrillation	Cardiac disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Vertigo	Ear and labyrinth disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Hyperparathyroidism	Endocrine disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Parathyroid gland enlargement	Endocrine disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Iritis	Eye disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Abdominal pain	Gastrointestinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Diarrhoea	Gastrointestinal disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Diverticulum intestinal	Gastrointestinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Duodenitis	Gastrointestinal disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Gastric ulcer	Gastrointestinal disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Gastritis	Gastrointestinal disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Gastritis erosive	Gastrointestinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Gastrointestinal haemorrhage	Gastrointestinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Haemorrhoids	Gastrointestinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Ileal perforation	Gastrointestinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Peritonitis	Gastrointestinal disorders	EG0003 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Upper gastrointestinal haemorrhage	Gastrointestinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Cardiac death	General disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Catheter related complication	General disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Catheter site haematoma	General disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Catheter site haemorrhage	General disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Catheter site phlebitis	General disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Mass	General disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Pyrexia	General disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Bile duct stenosis	Hepatobiliary disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Cholelithiasis	Hepatobiliary disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Anaphylactic reaction	Immune system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Abdominal abscess	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Acute sinusitis	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Aeromona infection	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Arteriovenous fistula site infection	Infections and infestations	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Bronchitis	Infections and infestations	EG0002 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Bronchopneumonia	Infections and infestations	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Catheter sepsis	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Cellulitis	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Clostridium difficile colitis	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Furuncle	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Gangrene	Infections and infestations	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Pneumonia	Infections and infestations	EG0007 affected432 at risk EG0013 affected76 at risk EG0021 affected124 at risk
Pyelonephritis chronic	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Pyonephrosis	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Salpingitis	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Sepsis	Infections and infestations	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Subcutaneous abscess	Infections and infestations	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Upper respiratory tract infection	Infections and infestations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Urinary tract infection	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Wound sepsis	Infections and infestations	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Ankle fracture	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Arteriovenous fistula aneurysm	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Arteriovenous fistula site complication	Injury, poisoning and procedural complications	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Arteriovenous fistula site haemorrhage	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Arteriovenous fistula thrombosis	Injury, poisoning and procedural complications	EG0005 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Device failure	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Dialysis device complication	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Eye injury	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Femoral neck fracture	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Fibula fracture	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Periprosthetic fracture	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Procedural hypotension	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Radius fracture	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Road traffic accident	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Shunt malfunction	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Shunt occlusion	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Shunt thrombosis	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Vascular pseudoaneurysm	Injury, poisoning and procedural complications	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Arteriogram coronary	Investigations	EG0001 affected432 at risk EG0011 affected76 at risk EG0022 affected124 at risk
Hepatic enzyme increased	Investigations	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Dehydration	Metabolism and nutrition disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Diabetes mellitus	Metabolism and nutrition disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Fluid overload	Metabolism and nutrition disorders	EG0002 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Fluid retention	Metabolism and nutrition disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Hyperglycaemia	Metabolism and nutrition disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Hyperkalaemia	Metabolism and nutrition disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Hypoglycaemia	Metabolism and nutrition disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Metabolic disorder	Metabolism and nutrition disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Osteoarthritis	Musculoskeletal and connective tissue disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Rotator cuff syndrome	Musculoskeletal and connective tissue disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Soft tissue haemorrhage	Musculoskeletal and connective tissue disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Lung neoplasm malignant	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Squamous cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Thyroid neoplasm	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Uterine cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Brain stem ischaemia	Nervous system disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Carotid artery stenosis	Nervous system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Cerebrovascular accident	Nervous system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Encephalomalacia	Nervous system disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Epilepsy	Nervous system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Haemorrhagic stroke	Nervous system disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Ischaemic stroke	Nervous system disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0022 affected124 at risk
Loss of consciousness	Nervous system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Subarachnoid haemorrhage	Nervous system disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Vertebrobasilar insufficiency	Nervous system disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Confusional state	Psychiatric disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Calculus bladder	Renal and urinary disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Reduced bladder capacity	Renal and urinary disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Renal artery thrombosis	Renal and urinary disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Renal failure chronic	Renal and urinary disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Benign prostatic hyperplasia	Reproductive system and breast disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Genital haemorrhage	Reproductive system and breast disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Acute pulmonary oedema	Respiratory, thoracic and mediastinal disorders	EG0002 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Chronic obstructive pulmonary disease	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Orthopnoea	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Pharyngeal haemorrhage	Respiratory, thoracic and mediastinal disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Pleural effusion	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0021 affected124 at risk
Pneumothorax	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Pulmonary oedema	Respiratory, thoracic and mediastinal disorders	EG0002 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Respiratory distress	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Respiratory failure	Respiratory, thoracic and mediastinal disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Decubitus ulcer	Skin and subcutaneous tissue disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Guttate psoriasis	Skin and subcutaneous tissue disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Skin ulcer	Skin and subcutaneous tissue disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Coronary arterial stent insertion	Surgical and medical procedures	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Accelerated hypertension	Vascular disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Aortic stenosis	Vascular disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Arterial occlusive disease	Vascular disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Arteriosclerosis	Vascular disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Arteriosclerosis obliterans	Vascular disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Brachiocephalic vein stenosis	Vascular disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Circulatory collapse	Vascular disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Extremity necrosis	Vascular disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0022 affected124 at risk
Haematoma	Vascular disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Hypertension	Vascular disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0022 affected124 at risk
Hypertensive crisis	Vascular disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0023 affected124 at risk
Hypovolaemic shock	Vascular disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Peripheral vascular disorder	Vascular disorders	EG0000 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Venous insufficiency	Vascular disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Venous occlusion	Vascular disorders	EG0001 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk

Other Adverse Events

Term	Organ System	Statistical Information
Anaemia	Blood and lymphatic system disorders	EG00034 affected432 at risk EG00113 affected76 at risk EG00222 affected124 at risk
Nephrogenic anaemia	Blood and lymphatic system disorders	EG0006 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Angina pectoris	Cardiac disorders	EG0005 affected432 at risk EG0011 affected76 at risk EG0024 affected124 at risk
Myocardial ischaemia	Cardiac disorders	EG0009 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Vertigo	Ear and labyrinth disorders	EG0006 affected432 at risk EG0011 affected76 at risk EG0024 affected124 at risk
Hyperparathyroidism	Endocrine disorders	EG00014 affected432 at risk EG0015 affected76 at risk EG00212 affected124 at risk
Hyperparathyroidism secondary	Endocrine disorders	EG0005 affected432 at risk EG0013 affected76 at risk EG0024 affected124 at risk
Conjunctivitis	Eye disorders	EG0006 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Abdominal distension	Gastrointestinal disorders	EG00014 affected432 at risk EG0010 affected76 at risk EG0021 affected124 at risk
Abdominal pain	Gastrointestinal disorders	EG00021 affected432 at risk EG0019 affected76 at risk EG00213 affected124 at risk
Abdominal pain upper	Gastrointestinal disorders	EG00025 affected432 at risk EG0018 affected76 at risk EG0027 affected124 at risk
Constipation	Gastrointestinal disorders	EG00032 affected432 at risk EG00114 affected76 at risk EG00214 affected124 at risk
Diarrhoea	Gastrointestinal disorders	EG00031 affected432 at risk EG00115 affected76 at risk EG00220 affected124 at risk
Duodenitis	Gastrointestinal disorders	EG0004 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Dyspepsia	Gastrointestinal disorders	EG00040 affected432 at risk EG00113 affected76 at risk EG0029 affected124 at risk
Flatulence	Gastrointestinal disorders	EG0009 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Gastritis	Gastrointestinal disorders	EG00010 affected432 at risk EG0013 affected76 at risk EG0022 affected124 at risk
Gastritis erosive	Gastrointestinal disorders	EG0009 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Gastrooesophageal reflux disease	Gastrointestinal disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Nausea	Gastrointestinal disorders	EG00050 affected432 at risk EG0018 affected76 at risk EG00213 affected124 at risk
Oesophagitis	Gastrointestinal disorders	EG0003 affected432 at risk EG0013 affected76 at risk EG0021 affected124 at risk
Toothache	Gastrointestinal disorders	EG0003 affected432 at risk EG0013 affected76 at risk EG0023 affected124 at risk
Vomiting	Gastrointestinal disorders	EG00037 affected432 at risk EG00115 affected76 at risk EG00213 affected124 at risk
Asthenia	General disorders	EG00019 affected432 at risk EG0013 affected76 at risk EG0022 affected124 at risk
Non-cardiac chest pain	General disorders	EG0004 affected432 at risk EG0012 affected76 at risk EG0022 affected124 at risk
Oedema peripheral	General disorders	EG00016 affected432 at risk EG0019 affected76 at risk EG0024 affected124 at risk
Pyrexia	General disorders	EG00012 affected432 at risk EG0012 affected76 at risk EG0027 affected124 at risk
Bronchitis	Infections and infestations	EG00015 affected432 at risk EG0018 affected76 at risk EG00211 affected124 at risk
Catheter sepsis	Infections and infestations	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Cystitis	Infections and infestations	EG0003 affected432 at risk EG0010 affected76 at risk EG0025 affected124 at risk
Gastroenteritis	Infections and infestations	EG0002 affected432 at risk EG0010 affected76 at risk EG0023 affected124 at risk
Influenza	Infections and infestations	EG00013 affected432 at risk EG0013 affected76 at risk EG0028 affected124 at risk
Nasopharyngitis	Infections and infestations	EG00013 affected432 at risk EG0018 affected76 at risk EG00214 affected124 at risk
Pharyngitis	Infections and infestations	EG0007 affected432 at risk EG0013 affected76 at risk EG0025 affected124 at risk
Respiratory tract infection	Infections and infestations	EG00010 affected432 at risk EG0014 affected76 at risk EG0020 affected124 at risk
Respiratory tract infection viral	Infections and infestations	EG0009 affected432 at risk EG0010 affected76 at risk EG0020 affected124 at risk
Rhinitis	Infections and infestations	EG0005 affected432 at risk EG0012 affected76 at risk EG0022 affected124 at risk
Upper respiratory tract infection	Infections and infestations	EG0007 affected432 at risk EG0014 affected76 at risk EG0028 affected124 at risk
Urinary tract infection	Infections and infestations	EG0005 affected432 at risk EG0013 affected76 at risk EG0026 affected124 at risk
Arteriovenous fistula site complication	Injury, poisoning and procedural complications	EG0007 affected432 at risk EG0016 affected76 at risk EG0022 affected124 at risk
Arteriovenous fistula site haematoma	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0025 affected124 at risk
Arteriovenous fistula thrombosis	Injury, poisoning and procedural complications	EG00013 affected432 at risk EG0013 affected76 at risk EG0025 affected124 at risk
Dialysis device complication	Injury, poisoning and procedural complications	EG0003 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Haemodialysis-induced symptom	Injury, poisoning and procedural complications	EG00022 affected432 at risk EG0018 affected76 at risk EG00213 affected124 at risk
Limb injury	Injury, poisoning and procedural complications	EG0001 affected432 at risk EG0011 affected76 at risk EG0023 affected124 at risk
Procedural hypertension	Injury, poisoning and procedural complications	EG00014 affected432 at risk EG0012 affected76 at risk EG0026 affected124 at risk
Procedural hypotension	Injury, poisoning and procedural complications	EG00016 affected432 at risk EG0016 affected76 at risk EG0029 affected124 at risk
Procedural pain	Injury, poisoning and procedural complications	EG0003 affected432 at risk EG0013 affected76 at risk EG0021 affected124 at risk
Blood parathyroid hormone increased	Investigations	EG00014 affected432 at risk EG0012 affected76 at risk EG0027 affected124 at risk
C-reactive protein increased	Investigations	EG0005 affected432 at risk EG0015 affected76 at risk EG0027 affected124 at risk
Electrocardiogram QT interval abnormal	Investigations	EG0002 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Haemoglobin decreased	Investigations	EG0003 affected432 at risk EG0010 affected76 at risk EG0023 affected124 at risk
Decreased appetite	Metabolism and nutrition disorders	EG00013 affected432 at risk EG0014 affected76 at risk EG0023 affected124 at risk
Fluid overload	Metabolism and nutrition disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Fluid retention	Metabolism and nutrition disorders	EG0008 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Hyperkalaemia	Metabolism and nutrition disorders	EG00015 affected432 at risk EG0016 affected76 at risk EG0027 affected124 at risk
Hyperphosphataemia	Metabolism and nutrition disorders	EG0007 affected432 at risk EG0013 affected76 at risk EG0022 affected124 at risk
Hypervolaemia	Metabolism and nutrition disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Hypocalcaemia	Metabolism and nutrition disorders	EG00032 affected432 at risk EG00112 affected76 at risk EG00210 affected124 at risk
Hypoglycaemia	Metabolism and nutrition disorders	EG0004 affected432 at risk EG0013 affected76 at risk EG0021 affected124 at risk
Iron deficiency	Metabolism and nutrition disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Arthralgia	Musculoskeletal and connective tissue disorders	EG00021 affected432 at risk EG0013 affected76 at risk EG0029 affected124 at risk
Back pain	Musculoskeletal and connective tissue disorders	EG00014 affected432 at risk EG00110 affected76 at risk EG0026 affected124 at risk
Bone pain	Musculoskeletal and connective tissue disorders	EG0006 affected432 at risk EG0012 affected76 at risk EG0025 affected124 at risk
Muscle spasms	Musculoskeletal and connective tissue disorders	EG0009 affected432 at risk EG0013 affected76 at risk EG0021 affected124 at risk
Musculoskeletal chest pain	Musculoskeletal and connective tissue disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Musculoskeletal pain	Musculoskeletal and connective tissue disorders	EG0006 affected432 at risk EG0014 affected76 at risk EG0027 affected124 at risk
Neck pain	Musculoskeletal and connective tissue disorders	EG0002 affected432 at risk EG0010 affected76 at risk EG0024 affected124 at risk
Osteochondrosis	Musculoskeletal and connective tissue disorders	EG00013 affected432 at risk EG0011 affected76 at risk EG0020 affected124 at risk
Pain in extremity	Musculoskeletal and connective tissue disorders	EG0009 affected432 at risk EG0013 affected76 at risk EG00213 affected124 at risk
Thyroid neoplasm	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0002 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Headache	Nervous system disorders	EG00031 affected432 at risk EG0019 affected76 at risk EG00212 affected124 at risk
Anxiety	Psychiatric disorders	EG0005 affected432 at risk EG0013 affected76 at risk EG0022 affected124 at risk
Insomnia	Psychiatric disorders	EG0006 affected432 at risk EG0011 affected76 at risk EG0024 affected124 at risk
Anuria	Renal and urinary disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Bronchitis chronic	Respiratory, thoracic and mediastinal disorders	EG0003 affected432 at risk EG0012 affected76 at risk EG0020 affected124 at risk
Chronic obstructive pulmonary disease	Respiratory, thoracic and mediastinal disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Cough	Respiratory, thoracic and mediastinal disorders	EG00016 affected432 at risk EG0018 affected76 at risk EG0029 affected124 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	EG00010 affected432 at risk EG0016 affected76 at risk EG0026 affected124 at risk
Epistaxis	Respiratory, thoracic and mediastinal disorders	EG0006 affected432 at risk EG0010 affected76 at risk EG0023 affected124 at risk
Oropharyngeal pain	Respiratory, thoracic and mediastinal disorders	EG0006 affected432 at risk EG0013 affected76 at risk EG0024 affected124 at risk
Pruritus	Skin and subcutaneous tissue disorders	EG00015 affected432 at risk EG0013 affected76 at risk EG0027 affected124 at risk
Rash	Skin and subcutaneous tissue disorders	EG0003 affected432 at risk EG0012 affected76 at risk EG0023 affected124 at risk
Skin ulcer	Skin and subcutaneous tissue disorders	EG0001 affected432 at risk EG0011 affected76 at risk EG0025 affected124 at risk
Urticaria	Skin and subcutaneous tissue disorders	EG0002 affected432 at risk EG0011 affected76 at risk EG0023 affected124 at risk
Renal transplant	Surgical and medical procedures	EG00012 affected432 at risk EG0017 affected76 at risk EG0025 affected124 at risk
Accelerated hypertension	Vascular disorders	EG0002 affected432 at risk EG0012 affected76 at risk EG0021 affected124 at risk
Arteriosclerosis	Vascular disorders	EG0002 affected432 at risk EG0011 affected76 at risk EG0023 affected124 at risk
Hypertension	Vascular disorders	EG00055 affected432 at risk EG00123 affected76 at risk EG00239 affected124 at risk
Hypotension	Vascular disorders	EG00013 affected432 at risk EG0015 affected76 at risk EG0025 affected124 at risk

Ancestor Terms

ID	Term
D051437	Renal Insufficiency
D007674	Kidney Diseases
D014570	Urologic Diseases
D052776	Female Urogenital Diseases
D005261	Female Urogenital Diseases and Pregnancy Complications
D000091642	Urogenital Diseases
D052801	Male Urogenital Diseases
D002908	Chronic Disease
D020969	Disease Attributes
D010335	Pathologic Processes
D013568	Pathological Conditions, Signs and Symptoms
D010760	Phosphorus Metabolism Disorders
D008659	Metabolic Diseases
D009750	Nutritional and Metabolic Diseases

Facility	Status	City	State	ZIP	Country	Contacts
		Graz			Austria

ID	Term
D051436	Renal Insufficiency, Chronic
D054559	Hyperphosphatemia

ID	Term
D011073	Polyamines
D000588	Amines
D009930	Organic Chemicals