A Phase 3, Randomized, Double Blind, Placebo-Controlled,... | NCT00506441

Status Module

Oversight Module

Label	Type	Description	Intervention Names
1	Experimental		Drug: MCI-196
2	Placebo Comparator		Drug: Placebo

Name	Type	Description	Arm Group Labels	Other Names
MCI-196	Drug	3g to 15g/day (3 times a day), Tablet, 12 weeks of flexible dose (Open-label) and 4 weeks of double blind	1

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
The Change in Serum Phosphorus From Week 12 to Week 16	The changes in serum phosphorus (mg/dL) from Week 12 to Week 16 (last observation post Week 12)	4 weeks (Week 12 to Week 16)

Measure	Description	Time Frame
Change From Baseline in Serum Phosphorus		12 weeks (Week 0 to Week 12)
Change From Baseline in PTH		12 weeks
Change From Baseline in Calcium

Eligibility Module

Name	Affiliation	Role
Professor	Information at Mitsubishi Pharma America	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
40576086	Derived	Natale P, Green SC, Ruospo M, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2025 Jun 27;6(6):CD006023. doi: 10.1002/14651858.CD006023.pub4.
26184491	Derived	Hertel J, Locatelli F, Spasovski G, Dimkovic N, Wanner C. Randomized, Double-Blind, Placebo-Controlled, Withdrawal Study of Colestilan after Dose Titration in Chronic Kidney Disease Dialysis Patients with Hyperphosphatemia. Nephron. 2015;130(4):229-38. doi: 10.1159/000431289. Epub 2015 Jul 10.

Results Section

Participant Flow Module

Arm/Group Information

ID	Title	Description
FG000	MCI-196	Open-label Period (Week 0 -12) ; 3, 6, 9, 12, or 15 g/ day as titrated Double-blind Period (Week 12 - 16) ; dose level at the end of dose titration in the Open-label period
FG001	Placebo

Baseline Characteristics Module

Outcome Measures Module

Adverse Events Module

More Info Module

Type

Title

Description

Population Description

Reporting Status

Anticipated Posting Date

Parameter Type

Dispersion Type

Unit of Measure

Calculate Percentage

Time Frame

Units Analyzed

Denominator Units Selected

Arm/Group Information

Denominators

Classes

Analyses

Primary

The Change in Serum Phosphorus From Week 12 to Week 16

The changes in serum phosphorus (mg/dL) from Week 12 to Week 16 (last observation post Week 12)

Intent-to-treat (ITT) 2 (The ITT2 population included all subjects who complete 12-weeks, receive a randomization number and receive at least one dose of study medication in the placebo-controlled withdrawal phase, either MCI-196 or placebo, and have at least one central phosphorus value after 12-weeks.)

Posted

Mean

Standard Deviation

mg / dL

4 weeks (Week 12 to Week 16)

ID	Title	Description
OG000	MCI-196 (Double-blind Period)	Double-blind Period (Week 12 - 16) ; dose level at the end of dose titration in the Open-label period
OG001	Placebo (Double-blind Period)	Double-blind Period (Week 12 - 16) ; dose level at the end of dose titration in the Open-label period

Units	Counts
Participants	OG00085 OG00183

Title

Denominators

Categories

Title	Measurements
	OG000-0.04± 1.49(-1.45 to -0.57) OG0010.71± 1.71

Secondary

Change From Baseline in Serum Phosphorus

ITT1 (The ITT1 population included all enrolled subjects who have taken at least one dose of study medication and have at least one central phosphorus value after the start of study medication.)

Posted

Mean

95% Confidence Interval

mg/dL

12 weeks (Week 0 to Week 12)

ID	Title	Description
OG000	MCI-196 (Open-label Period)	3, 6, 9, 12, or 15g/day as titrated (Week 0 -12)

Units	Counts
Participants	OG000241

Secondary

Change From Baseline in PTH

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in Calcium

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in Calcium x Phosphorus Ion Product

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in Total Cholesterol

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in LDL Cholesterol

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in HDL Cholesterol

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in VLDL Cholesterol

Not Posted

12 weeks

Participants

Secondary

Change From Baseline in Triglyceride

Not Posted

12 weeks

Participants

Secondary

Incidence of Adverse Events

Not Posted

12 weeks (Week 0-12) and 4 weeks (Week 12-16)

Participants

Arm/Groups

ID	Title	Description	Serious Events (Affected)	Serious Events (At Risk)	Other Events (Affected)	Other Events (At Risk)
EG000	MCI-196 (Open-label Period)	3, 6, 9, 12, or 15 g/ day as titrated (Week 0-12)	37	245	161	245
EG001	MCI-196 (Double-blind Period)	dose level at the end of dose titration in the Open-label period (Week 12-16) One subject who was randomized to placebo and another subject who was randomized to MCI-196 took both placebo and MCI-196 during the double-blind period. They have therefore been included in the MCI-196 group for the safety evaluation for the double-blind period.	10	86	34	86
EG002	Placebo (Double-blind Period)	dose level at the end of dose titration in the Open-label period (Week 12-16) One subject who was randomized to placebo and another subject who was randomized to MCI-196 took both placebo and MCI-196 during the double-blind period. They have therefore been included in the MCI-196 group for the safety evaluation for the double-blind period.	7	83	25	83

Serious Adverse Events

Term	Organ System	Statistical Information
Diabetic ketoacidosis	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hyperkalaemia	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Diabetes mellitus inadequate control	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Fluid overload	Metabolism and nutrition disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Diabetic foot	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Respiratory failure	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Acute respiratory failure	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Chronic obstructive pulmonary disease	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Tracheal stenosis	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pulmonary oedema	Respiratory, thoracic and mediastinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Asthma	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Wheezing	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Sepsis	Infections and infestations	EG0002 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Pneumonia	Infections and infestations	EG0003 affected245 at risk EG0012 affected86 at risk EG0020 affected83 at risk
Subcutaneous abscess	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cellulitis	Infections and infestations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Bronchitis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous graft site infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Staphylococcal infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Osteomyelitis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Gangrene	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Staphylococcal bacteraemia	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Non-cardiac chest pain	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pyrexia	General disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Catheter site haemorrhage	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Chest pain	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Duodenitis	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Gastritis	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Small intestinal haemorrhage	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pancreatitis acute	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Nausea	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vomiting	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Peritoneal haemorrhage	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Peritonitis	Gastrointestinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Transient ischaemic attack	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Syncope	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Haemorrhagic stroke	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Anaemia	Blood and lymphatic system disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Coagulopathy	Blood and lymphatic system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypertension	Vascular disorders	EG0003 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Hypotension	Vascular disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Rectal cancer	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Angina unstable	Cardiac disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Myocardial infarction	Cardiac disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Atrial fibrillation	Cardiac disorders	EG0002 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Acute myocardial infarction	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Atrioventricular block complete	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Bradycardia	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cardiomyopathy	Cardiac disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Angina pectoris	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cardiac failure congestive	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pericarditis	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cholelithiasis	Hepatobiliary disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Liver function test abnormal	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Colonoscopy abnormal	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vascular graft complication	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Humerus fracture	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous graft thrombosis	Injury, poisoning and procedural complications	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
In-stent coronary artery restenosis	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vascular graft occlusion	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vaginal haemorrhage	Reproductive system and breast disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Delirium	Psychiatric disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hydronephrosis	Renal and urinary disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Renal cyst	Renal and urinary disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Neck pain	Musculoskeletal and connective tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Skin ulcer	Skin and subcutaneous tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula occlusion	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula site haemorrhage	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Graft thrombosis	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Pericardial effusion	Cardiac disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Cardiac arrest	Cardiac disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Shock haemorrhagic	Vascular disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Superior vena caval occlusion	Vascular disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Accelerated hypertension	Vascular disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Gastroenteritis	Infections and infestations	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Septic shock	Infections and infestations	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Urinary tract infection	Infections and infestations	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Catheter related infection	Infections and infestations	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Hypoxia	Respiratory, thoracic and mediastinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Upper gastrointestinal haemorrhage	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Diverticulitis intestinal haemorrhagic	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Diabetic gastroparesis	Gastrointestinal disorders	EG0000 events0 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Enteritis	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Goitre	Endocrine disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Neuropathic arthropathy	Musculoskeletal and connective tissue disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Metastases to liver	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk

Other Adverse Events

Term	Organ System	Statistical Information
Arteriovenous fistula site haematoma	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula site complication	Injury, poisoning and procedural complications	EG00011 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Limb injury	Injury, poisoning and procedural complications	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Fall	Injury, poisoning and procedural complications	EG0002 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula thrombosis	Injury, poisoning and procedural complications	EG0003 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Arteriovenous graft thrombosis	Injury, poisoning and procedural complications	EG0006 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vascular graft complication	Injury, poisoning and procedural complications	EG0002 affected245 at risk EG0010 affected86 at risk EG0022 affected83 at risk
Rib fracture	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vascular access complication	Injury, poisoning and procedural complications	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula site haemorrhage	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Haemodialysis-induced symptom	Injury, poisoning and procedural complications	EG0005 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Procedural hypotension	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Procedural pain	Injury, poisoning and procedural complications	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Excoriation	Injury, poisoning and procedural complications	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Diverticulitis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Urinary tract infection	Infections and infestations	EG0006 affected245 at risk EG0010 affected86 at risk EG0023 affected83 at risk
Influenza	Infections and infestations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cellulitis	Infections and infestations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hordeolum	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Nasopharyngitis	Infections and infestations	EG0004 affected245 at risk EG0011 affected86 at risk EG0022 affected83 at risk
Tooth infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Upper respiratory tract infection	Infections and infestations	EG0009 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Gastroenteritis	Infections and infestations	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Bronchitis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Staphylococcal sepsis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Ear infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Lymphangitis	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Lower respiratory tract infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Arteriovenous fistula site infection	Infections and infestations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hepatitis C	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Fungal infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Localised infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Eyelid infection	Infections and infestations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Nausea	Gastrointestinal disorders	EG00021 affected245 at risk EG0014 affected86 at risk EG0020 affected83 at risk
Diarrhoea	Gastrointestinal disorders	EG00022 affected245 at risk EG0013 affected86 at risk EG0023 affected83 at risk
Abdominal pain	Gastrointestinal disorders	EG0005 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Diverticulum	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Melaena	Gastrointestinal disorders	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Dyspepsia	Gastrointestinal disorders	EG00012 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vomiting	Gastrointestinal disorders	EG00018 affected245 at risk EG0013 affected86 at risk EG0020 affected83 at risk
Abdominal discomfort	Gastrointestinal disorders	EG0004 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Abdominal distension	Gastrointestinal disorders	EG0005 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hiatus hernia	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Constipation	Gastrointestinal disorders	EG00015 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Gastrooesophageal reflux disease	Gastrointestinal disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Abdominal pain upper	Gastrointestinal disorders	EG0004 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Dry mouth	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hyperchlorhydria	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Flatulence	Gastrointestinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Abdominal mass	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Peritonitis	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Tooth disorder	Gastrointestinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Skin ulcer	Skin and subcutaneous tissue disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pruritus	Skin and subcutaneous tissue disorders	EG0006 affected245 at risk EG0012 affected86 at risk EG0020 affected83 at risk
Dry skin	Skin and subcutaneous tissue disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Rash	Skin and subcutaneous tissue disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Skin discolouration	Skin and subcutaneous tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pain of skin	Skin and subcutaneous tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cough	Respiratory, thoracic and mediastinal disorders	EG0005 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Sleep apnoea syndrome	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dyspnoea	Respiratory, thoracic and mediastinal disorders	EG00011 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Oropharyngeal pain	Respiratory, thoracic and mediastinal disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pleural effusion	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Epistaxis	Respiratory, thoracic and mediastinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Wheezing	Respiratory, thoracic and mediastinal disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Productive cough	Respiratory, thoracic and mediastinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Bronchospasm	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Rhinorrhoea	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Throat irritation	Respiratory, thoracic and mediastinal disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dysphonia	Respiratory, thoracic and mediastinal disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vision blurred	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Conjunctivitis	Eye disorders	EG0003 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Visual impairment	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Lacrimation increased	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cataract	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Eye haemorrhage	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Ocular hyperaemia	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Eye swelling	Eye disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Back pain	Musculoskeletal and connective tissue disorders	EG00011 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Muscular weakness	Musculoskeletal and connective tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pain in extremity	Musculoskeletal and connective tissue disorders	EG0008 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Arthralgia	Musculoskeletal and connective tissue disorders	EG0002 affected245 at risk EG0013 affected86 at risk EG0021 affected83 at risk
Pain in jaw	Musculoskeletal and connective tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Musculoskeletal chest pain	Musculoskeletal and connective tissue disorders	EG0001 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Musculoskeletal pain	Musculoskeletal and connective tissue disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Muscle spasms	Musculoskeletal and connective tissue disorders	EG0005 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Arthritis	Musculoskeletal and connective tissue disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Neck pain	Musculoskeletal and connective tissue disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Cardiac failure acute	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Sinus tachycardia	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Atrial fibrillation	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cardiac failure congestive	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Conduction disorder	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Bradycardia	Cardiac disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Chills	General disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Malaise	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Oedema peripheral	General disorders	EG0006 affected245 at risk EG0013 affected86 at risk EG0021 affected83 at risk
Chest pain	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Pyrexia	General disorders	EG0006 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Asthenia	General disorders	EG0007 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Fatigue	General disorders	EG0004 affected245 at risk EG0012 affected86 at risk EG0020 affected83 at risk
Gait disturbance	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Generalised oedema	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Oedema	General disorders	EG0004 affected245 at risk EG0012 affected86 at risk EG0021 affected83 at risk
Influenza like illness	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Tenderness	General disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Face oedema	General disorders	EG0003 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Thrombocytopenia	Blood and lymphatic system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Anaemia	Blood and lymphatic system disorders	EG0001 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Haemorrhagic anaemia	Blood and lymphatic system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypotension	Vascular disorders	EG0004 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Hypertension	Vascular disorders	EG0006 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Haematoma	Vascular disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hot flush	Vascular disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Sinus headache	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Headache	Nervous system disorders	EG00010 affected245 at risk EG0011 affected86 at risk EG0022 affected83 at risk
Paraesthesia	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Syncope	Nervous system disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Somnolence	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Neuropathy peripheral	Nervous system disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dizziness postural	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dizziness	Nervous system disorders	EG0005 affected245 at risk EG0013 affected86 at risk EG0020 affected83 at risk
Restless legs syndrome	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dysgeusia	Nervous system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Blood phosphorus increased	Investigations	EG0004 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Blood phosphorus decreased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Electrocardiogram QT prolonged	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Body temperature increased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Prothrombin time prolonged	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Weight decreased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Blood triglycerides increased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Carbon dioxide decreased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
High density lipoprotein decreased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Urine output decreased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Very low density lipoprotein increased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Vitamin D decreased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Blood alkaline phosphatase increased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Blood calcium decreased	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Blood parathyroid hormone increased	Investigations	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cardiac murmur	Investigations	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Iron deficiency	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Decreased appetite	Metabolism and nutrition disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypocalcaemia	Metabolism and nutrition disorders	EG0006 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hyperkalaemia	Metabolism and nutrition disorders	EG0002 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Fluid overload	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Metabolic acidosis	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypercalcaemia	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Calcium deficiency	Metabolism and nutrition disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypoglycaemia	Metabolism and nutrition disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypokalaemia	Metabolism and nutrition disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Anxiety	Psychiatric disorders	EG0004 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Insomnia	Psychiatric disorders	EG0005 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Sleep disorder	Psychiatric disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Mental status changes	Psychiatric disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Disorientation	Psychiatric disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hypothyroidism	Endocrine disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Hyperparathyroidism secondary	Endocrine disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Drug hypersensitivity	Immune system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Seasonal allergy	Immune system disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Cholelithiasis	Hepatobiliary disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Nephrolithiasis	Renal and urinary disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Dysuria	Renal and urinary disorders	EG0002 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Menorrhagia	Reproductive system and breast disorders	EG0001 affected245 at risk EG0010 affected86 at risk EG0020 affected83 at risk
Haemorrhoids	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Abdominal pain	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Lip pain	Gastrointestinal disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Intervertebral disc protrusion	Musculoskeletal and connective tissue disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Keloid scar	Skin and subcutaneous tissue disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Infected skin ulcer	Infections and infestations	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Arteriovenous graft site infection	Infections and infestations	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Eye infection	Infections and infestations	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Intermittent claudication	Vascular disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Cardiomegaly	Cardiac disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Bundle branch block	Cardiac disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Myocardial ischaemia	Cardiac disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Bundle branch block right	Cardiac disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Tachycardia	Cardiac disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Hypoacusis	Ear and labyrinth disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Ear pain	Ear and labyrinth disorders	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Muscle strain	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Arteriovenous graft site haemorrhage	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Graft haemorrhage	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Procedural hypertension	Injury, poisoning and procedural complications	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Folate deficiency	Metabolism and nutrition disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Vitamin D deficiency	Metabolism and nutrition disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Dehydration	Metabolism and nutrition disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk
Gamma-glutamyltransferase increased	Investigations	EG0000 affected245 at risk EG0011 affected86 at risk EG0021 affected83 at risk
Osteocalcin increased	Investigations	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Basal cell carcinoma	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0000 affected245 at risk EG0010 affected86 at risk EG0021 affected83 at risk
Renal pain	Renal and urinary disorders	EG0000 affected245 at risk EG0011 affected86 at risk EG0020 affected83 at risk

Facility	Status	City	State	ZIP	Country	Contacts
		Glendale	Arizona		United States

ID	Term
D051437	Renal Insufficiency
D007674	Kidney Diseases
D014570	Urologic Diseases
D052776	Female Urogenital Diseases
D005261	Female Urogenital Diseases and Pregnancy Complications
D000091642	Urogenital Diseases
D052801	Male Urogenital Diseases
D002908	Chronic Disease
D020969	Disease Attributes
D010335	Pathologic Processes
D013568	Pathological Conditions, Signs and Symptoms
D010760	Phosphorus Metabolism Disorders
D008659	Metabolic Diseases
D009750	Nutritional and Metabolic Diseases