A Study of MCI-196 in Chronic Kidney Disease Subjects on... | NCT00542386

NCT00542386

Status Module

Sponsor/Collaborators Module

Oversight Module

Description Module

Conditions Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Label	Type	Description	Intervention Names
1	Experimental		Drug: MCI-196
2	Placebo Comparator		Drug: Placebo

Name	Type	Description	Arm Group Labels	Other Names
MCI-196	Drug	3g to 15g/day (3 times a day), Tablet, 12 weeks of fixed dose of study	1

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
The Change in Serum Phosphorus	The change from baseline to week 12	12 weeks
The Change in LDL-cholesterol	The percentage change from baseline to week 12	12 weeks

Measure	Description	Time Frame
The Change in Total-cholesterol		12 weeks
The Change in HDL-cholesterol		12 weeks
The Change in Triglycerides

Eligibility Module

Contacts/Locations Module

Name	Affiliation	Role
Professor	Information at Mitsubishi Pharma Europe	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
40576086	Derived	Natale P, Green SC, Ruospo M, Craig JC, Vecchio M, Elder GJ, Strippoli GF. Phosphate binders for preventing and treating chronic kidney disease-mineral and bone disorder (CKD-MBD). Cochrane Database Syst Rev. 2025 Jun 27;6(6):CD006023. doi: 10.1002/14651858.CD006023.pub4.

IPD Sharing Statement Module

No data available

No data is available for this block.

Results Section

Participant Flow Module

ID	Title	Description
FG000	MCI-196: 3 g	MCI-196: 3 g/ day
FG001	MCI-196: 6 g	MCI-196: 6 g/ day
FG002

Baseline Characteristics Module

Outcome Measures Module

Adverse Events Module

More Info Module

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Submission Tracking

No data available

No data is available for this block.

Condition Browse Module

Intervention Browse Module

Masking Info

Each one subject in the MCI-196 9 g group, MCI-196 12 g group, and MCI-196 15 g group were randomised but did not receive any study medication. Therefore these 3 subjects were excluded in the baseline characteristics analysis population.

Arm/Group Information

ID	Title	Description
BG000	MCI-196: 3 g	MCI-196: 3 g/ day
BG001	MCI-196: 6 g	MCI-196: 6 g/ day
BG002	MCI-196: 9 g	MCI-196: 9 g/ day
BG003	MCI-196: 12 g	MCI-196: 12 g/ day
BG004	MCI-196: 15 g	MCI-196: 15 g/ day
BG005	Pooled Placebo	Placebo 9 tablets, 12 tablets and 15 tablets/ day
BG006	Total	Total of all reporting groups

Baseline Measures

Title

Description

Population Description

Parameter Type

Dispersion Type

Unit of Measure

Calculate Percentage

Denominator Units Selected

Denominators

Classes

Age, Continuous

Mean

Standard Deviation

years

Title

Denominators

Categories

Title	Measurements
	OG000-0.23± 1.62 OG001-0.77± 1.97 OG002-0.97± 1.68 OG003

Primary

The Change in LDL-cholesterol

The percentage change from baseline to week 12

ITT: The ITT population included all subjects who received a randomisation number, took study medication, and had at least 1 central laboratory serum phosphorus or LDL-C value after the start of study medication.

Posted

Mean

Standard Deviation

Percent change

12 weeks

ID	Title	Description
OG000	MCI-196: 3 g	MCI-196: 3 g/ day
OG001	MCI-196: 6 g	MCI-196: 6 g/ day
OG002	MCI-196: 9 g	MCI-196: 9 g/ day
OG003	MCI-196: 12 g	MCI-196: 12 g/ day
OG004	MCI-196: 15 g	MCI-196: 15 g/ day
OG005

Secondary

The Change in Total-cholesterol

Not Posted

12 weeks

Participants

Secondary

The Change in HDL-cholesterol

Not Posted

12 weeks

Participants

Secondary

The Change in Triglycerides

Not Posted

12 weeks

Participants

Secondary

The Change in PTH

Not Posted

12 weeks

Participants

Secondary

The Change in Ca

Not Posted

12 weeks

Participants

Secondary

The Change in Ca x P Ion Product

Not Posted

12 weeks

Participants

Secondary

The Incidence of Adverse Events

Not Posted

12 weeks

Participants

Arm/Groups

ID	Title	Description	Serious Events (Affected)	Serious Events (At Risk)	Other Events (Affected)	Other Events (At Risk)
EG000	MCI-196: 3 g	MCI-196: 3 g/ day	3	104	47	104
EG001	MCI-196: 6 g	MCI-196: 6 g/ day	1	102	44	102
EG002	MCI-196: 9 g	MCI-196: 9 g/ day	2	98	49	98
EG003	MCI-196: 12 g	MCI-196: 12 g/ day	7	102	53	102
EG004	MCI-196: 15 g	MCI-196: 15 g/ day	5	101	59	101
EG005	Pooled Placebo	Placebo 9 tablets, 12 tablets and 15 tablets/ day	8	132	65	132

Serious Adverse Events

Term	Organ System	Statistical Information
Ischaemic cardiomyopathy	Cardiac disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG0030 affected102 at risk EG0040 affected101 at risk EG0050 affected132 at risk
Cardiovascular insufficiency	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pericarditis	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Atrial fibrillation	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pyelonephritis chronic	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Cellulitis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Upper respiratory tract infection	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Acute sinusitis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Abscess limb	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Sepsis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hepatitis B	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Mass	General disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Catheter site phlebitis	General disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hypertension	Vascular disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Azotaemia	Renal and urinary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Renal failure chronic	Renal and urinary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pulmonary oedema	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Choking	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Iritis	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Ascites	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Nausea	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Vomiting	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Abdominal pain	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Retroperitoneal haematoma	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Haemorrhoids	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastrointestinal haemorrhage	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Renal transplant	Surgical and medical procedures	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Haemorrhagic stroke	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arteriovenous fistula thrombosis	Injury, poisoning and procedural complications	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Eye injury	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Shunt thrombosis	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Kidney rupture	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Road traffic accident	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Procedural hypotension	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003

Other Adverse Events

Term	Organ System	Statistical Information
Anaemia	Blood and lymphatic system disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG0031 affected102 at risk EG0042 affected101 at risk EG0050 affected132 at risk
Haemorrhagic disorder	Blood and lymphatic system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Lymphadenopathy	Blood and lymphatic system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hypertensive crisis	Vascular disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hypotension	Vascular disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Hypertension	Vascular disorders	EG0003 affected104 at risk EG0016 affected102 at risk EG0026 affected98 at risk EG003
Aortic stenosis	Vascular disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Haematoma	Vascular disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Blood pressure fluctuation	Vascular disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arteriosclerosis obliterans	Vascular disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Headache	Nervous system disorders	EG0003 affected104 at risk EG0011 affected102 at risk EG0022 affected98 at risk EG003
Hypertonia	Nervous system disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hypotonia	Nervous system disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Intercostal neuralgia	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Tremor	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Uraemic neuropathy	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Paraesthesia	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Convulsions local	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Encephalopathy	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dizziness	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dysgeusia	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Somnolence	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Parosmia	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Tonic convulsion	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Polyneuropathy	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Trigeminal neuralgia	Nervous system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Breast abscess	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Injection site abscess	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Urinary tract infection	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Upper respiratory tract infection	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Bacterial infection	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Varicella	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastroenteritis	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Laryngitis	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Nasopharyngitis	Infections and infestations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Cystitis	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Cellulitis	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Bronchitis	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Vaginitis bacterial	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Cervicitis	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Salpingo-oophoritis	Infections and infestations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Influenza	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Pharyngitis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Sinusitis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Respiratory tract infection	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Helicobacter infection	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Herpes zoster	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pulmonary tuberculosis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Respiratory tract infection viral	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Oesophageal candidiasis	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hepatitis C	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Viral infection	Infections and infestations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Asthenia	General disorders	EG0004 affected104 at risk EG0011 affected102 at risk EG0023 affected98 at risk EG003
Pyrexia	General disorders	EG0004 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Chills	General disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Chest discomfort	General disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Malaise	General disorders	EG0000 affected104 at risk EG0012 affected102 at risk EG0020 affected98 at risk EG003
Oedema peripheral	General disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Pain	General disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Thirst	General disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Fatigue	General disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Catheter related complication	General disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Non-cardiac chest pain	General disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Congestive cardiomyopathy	Cardiac disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Myocardial ischaemia	Cardiac disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Ventricular extrasystoles	Cardiac disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Supraventricular extrasystoles	Cardiac disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Aortic valve calcification	Cardiac disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Angina pectoris	Cardiac disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Tachycardia	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Extrasystoles	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Palpitations	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Conduction disorder	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Bradycardia	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Atrioventricular block first degree	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Bundle branch block left	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arrhythmia supraventricular	Cardiac disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dyspnoea	Respiratory, thoracic and mediastinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Epistaxis	Respiratory, thoracic and mediastinal disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Cough	Respiratory, thoracic and mediastinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Throat irritation	Respiratory, thoracic and mediastinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Asthma	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Rhinitis allergic	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Oropharyngeal pain	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Nasal dryness	Respiratory, thoracic and mediastinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Toothache	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Diarrhoea	Gastrointestinal disorders	EG0005 affected104 at risk EG0015 affected102 at risk EG0026 affected98 at risk EG003
Nausea	Gastrointestinal disorders	EG0004 affected104 at risk EG0019 affected102 at risk EG00212 affected98 at risk EG003
Hyperchlorhydria	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Flatulence	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Abdominal pain	Gastrointestinal disorders	EG0003 affected104 at risk EG0012 affected102 at risk EG0024 affected98 at risk EG003
Frequent bowel movements	Gastrointestinal disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Abdominal pain upper	Gastrointestinal disorders	EG0001 affected104 at risk EG0013 affected102 at risk EG0020 affected98 at risk EG003
Dyspepsia	Gastrointestinal disorders	EG0004 affected104 at risk EG0018 affected102 at risk EG0027 affected98 at risk EG003
Proctalgia	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Constipation	Gastrointestinal disorders	EG0003 affected104 at risk EG0011 affected102 at risk EG0026 affected98 at risk EG003
Eructation	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Epigastric discomfort	Gastrointestinal disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Irritable bowel syndrome	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Vomiting	Gastrointestinal disorders	EG0002 affected104 at risk EG0014 affected102 at risk EG0028 affected98 at risk EG003
Abdominal discomfort	Gastrointestinal disorders	EG0001 affected104 at risk EG0012 affected102 at risk EG0021 affected98 at risk EG003
Dry mouth	Gastrointestinal disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Odynophagia	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Abnormal faeces	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dyschezia	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Faecaloma	Gastrointestinal disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Faeces discoloured	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Infrequent bowel movements	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Retching	Gastrointestinal disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastritis	Gastrointestinal disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Abdominal distension	Gastrointestinal disorders	EG0000 affected104 at risk EG0013 affected102 at risk EG0022 affected98 at risk EG003
Gastritis erosive	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Painful defaecation	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Peritonitis	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastrointestinal hypermotility	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Defaecation urgency	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Faeces pale	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Haemorrhoidal haemorrhage	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Haemorrhoids	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Diarrhoea haemorrhagic	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastric disorder	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dysphagia	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastrointestinal pain	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastric ulcer	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Abdominal rigidity	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Duodenal ulcer	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Erosive oesophagitis	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Tongue disorder	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Duodenitis	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastrointestinal sounds abnormal	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Gastrointestinal motility disorder	Gastrointestinal disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arthritis	Musculoskeletal and connective tissue disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Neck pain	Musculoskeletal and connective tissue disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pain in extremity	Musculoskeletal and connective tissue disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Muscle spasms	Musculoskeletal and connective tissue disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arthralgia	Musculoskeletal and connective tissue disorders	EG0002 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Bone pain	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Pain in jaw	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Back pain	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Musculoskeletal pain	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Myalgia	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arthropathy	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Osteochondrosis	Musculoskeletal and connective tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Blood parathyroid hormone increased	Investigations	EG0002 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Blood pressure increased	Investigations	EG0002 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Weight increased	Investigations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Weight decreased	Investigations	EG0001 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Blood phosphorus increased	Investigations	EG0003 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Cardiac murmur	Investigations	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Body temperature increased	Investigations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Aspartate aminotransferase increased	Investigations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Blood creatine phosphokinase increased	Investigations	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Gamma-glutamyltransferase increased	Investigations	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Carotid bruit	Investigations	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Blood alkaline phosphatase increased	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Blood pressure decreased	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Heart rate increased	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
ECG signs of myocardial ischaemia	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Blood calcium decreased	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Blood phosphorus decreased	Investigations	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Haemodialysis-induced symptom	Injury, poisoning and procedural complications	EG0002 affected104 at risk EG0012 affected102 at risk EG0020 affected98 at risk EG003
Procedural hypotension	Injury, poisoning and procedural complications	EG0002 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Contusion	Injury, poisoning and procedural complications	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Traumatic haematoma	Injury, poisoning and procedural complications	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Procedural hypertension	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0023 affected98 at risk EG003
Extensive interdialytic weight gain	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Operative haemorrhage	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arteriovenous fistula thrombosis	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Fall	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Ear injury	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Arteriovenous fistula site complication	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Thermal burn	Injury, poisoning and procedural complications	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hyperphosphataemia	Metabolism and nutrition disorders	EG0003 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Decreased appetite	Metabolism and nutrition disorders	EG0002 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Cachexia	Metabolism and nutrition disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Polydipsia	Metabolism and nutrition disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Hyperkalaemia	Metabolism and nutrition disorders	EG0001 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Hypocalcaemia	Metabolism and nutrition disorders	EG0002 affected104 at risk EG0012 affected102 at risk EG0023 affected98 at risk EG003
Fluid retention	Metabolism and nutrition disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hyperlipidaemia	Metabolism and nutrition disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Abnormal weight gain	Metabolism and nutrition disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Appetite disorder	Metabolism and nutrition disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Increased appetite	Metabolism and nutrition disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Rash pruritic	Skin and subcutaneous tissue disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Pruritus	Skin and subcutaneous tissue disorders	EG0003 affected104 at risk EG0011 affected102 at risk EG0022 affected98 at risk EG003
Alopecia	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Cutaneous vasculitis	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Rash papular	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dermatitis allergic	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Erythema	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Cutaneous lupus erythematosus	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Dry skin	Skin and subcutaneous tissue disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Sleep disorder	Psychiatric disorders	EG0001 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Insomnia	Psychiatric disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Anxiety	Psychiatric disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0022 affected98 at risk EG003
Hallucination, auditory	Psychiatric disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Decreased activity	Psychiatric disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Emotional distress	Psychiatric disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Renal transplant	Surgical and medical procedures	EG0001 affected104 at risk EG0011 affected102 at risk EG0021 affected98 at risk EG003
Nephrectomy	Surgical and medical procedures	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Vertigo	Ear and labyrinth disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Cerumen impaction	Ear and labyrinth disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Menorrhagia	Reproductive system and breast disorders	EG0000 affected104 at risk EG0012 affected102 at risk EG0020 affected98 at risk EG003
Oligomenorrhoea	Reproductive system and breast disorders	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Breast pain	Reproductive system and breast disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Fibroadenoma of breast	Neoplasms benign, malignant and unspecified (incl cysts and polyps)	EG0000 affected104 at risk EG0011 affected102 at risk EG0020 affected98 at risk EG003
Hyperparathyroidism	Endocrine disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Hyperparathyroidism secondary	Endocrine disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Parathyroid disorder	Endocrine disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hyperthyroidism	Endocrine disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hypersensitivity	Immune system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Drug hypersensitivity	Immune system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Kidney transplant rejection	Immune system disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Conjunctivitis	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Visual acuity reduced	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0021 affected98 at risk EG003
Eye haemorrhage	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Ocular hyperaemia	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Myopia	Eye disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hepatic cirrhosis	Hepatobiliary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hepatitis	Hepatobiliary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Cholelithiasis	Hepatobiliary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Hepatitis toxic	Hepatobiliary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003
Biliary colic	Hepatobiliary disorders	EG0000 affected104 at risk EG0010 affected102 at risk EG0020 affected98 at risk EG003

ID	Term
D051436	Renal Insufficiency, Chronic
D054559	Hyperphosphatemia
D050171	Dyslipidemias

Ancestor Terms

ID	Term
D051437	Renal Insufficiency
D007674	Kidney Diseases
D014570	Urologic Diseases
D052776	Female Urogenital Diseases
D005261	Female Urogenital Diseases and Pregnancy Complications
D000091642	Urogenital Diseases
D052801	Male Urogenital Diseases
D002908	Chronic Disease
D020969	Disease Attributes
D010335	Pathologic Processes
D013568	Pathological Conditions, Signs and Symptoms
D010760	Phosphorus Metabolism Disorders
D008659	Metabolic Diseases
D009750	Nutritional and Metabolic Diseases
D052439	Lipid Metabolism Disorders

ID	Term
C106574	cholebine

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Facility	Status	City	State	ZIP	Country	Contacts
		Ajka			Hungary