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| ID | Type | Description | Link |
|---|---|---|---|
| MK0524A-015 | |||
| 2007_612 |
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To determine the most effective daily dose of MK0524A when compared with placebo after the 8-week treatment period for Niacin Induce Flushing (NIF).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0524A, /Duration of Treatment : 8 Weeks | Drug | |||
| Comparator : placebo (unspecified) /Duration of Treatment : 8 Weeks | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the most effective daily dose and measurements to assess acute and chronic (long-lasting) Niacin Induce Flushing (NIF). | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the the time points of Niacin Induce Flushing (NIF) across the 8-week treatment period. | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17559750 | Background | Norquist JM, Watson DJ, Yu Q, Paolini JF, McQuarrie K, Santanello NC. Validation of a questionnaire to assess niacin-induced cutaneous flushing. Curr Med Res Opin. 2007 Jul;23(7):1549-60. doi: 10.1185/030079907x199637. | |
| 18410350 | Background | Paolini JF, Mitchel YB, Reyes R, Thompson-Bell S, Yu Q, Lai E, Watson DJ, Norquist JM, Sisk CM, Bays HE. Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: results from a randomised placebo-controlled clinical trial. Int J Clin Pract. 2008 Jun;62(6):896-904. doi: 10.1111/j.1742-1241.2008.01739.x. Epub 2008 Apr 10. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| CSR Snyopsis | View IPD |
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| ID | Term |
|---|---|
| D005483 | Flushing |
| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000081206 | Duration of Therapy |
| ID | Term |
|---|---|
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
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