A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers

A Study to Evaluate the Ability of the HM74A Agonist GSK256073A to Block Niacin-induced Flushing in Healthy Adult Subjects

To test the ability of GSK256073 to block niacin-induced flushing when GSK256073 and niacin are co-administered as single doses to HVTs.

Inclusion Criteria:

• Adult males between 18 and 55 years of age, inclusive.
• Healthy subjects
• Body weight > 50 kg (110 pounds) and body mass index (BMI) between 19 and 31 where:
• Subjects with QTc < 450 msec at screening

Exclusion Criteria:

• History of significant cardiac arrhythmias
• Active peptic ulcer disease (PUD) and/or history of PUD
• History of gout and/or hyperuricemia
• History of Gilbert's syndrome
• History of recurrent indigestion, stomach upset or diarrhea
• History of other than rare (once yearly or less) flushing
• Recurrent skin rash or psoriasis
• History of kidney stones