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| Name | Class |
|---|---|
| University of Virginia | OTHER |
| James Madison University | OTHER |
| Eastern Virginia Medical School | OTHER |
Purpose: to build a library of normal tear lacritin values by collecting tears from normal adult human subjects and to develop a non-invasive clinical assay for lacritin. Such an assay will provide more sensitive indicators of eye disease for clinicians and determine if a particular therapy, such as recombinant lacritin drops, is of benefit.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tear Collection | Procedure | The tear sample will be collected from the left eye of each subject. Subjects wearing contact lenses will be instructed to remove their lenses and wait at least 5 minutes before proceeding with the tear collection procedure. The patient will then be instructed to sit with eyes gently closed for two minutes after instilling one (1) drop of 0.5% proparacaine on the cornea and conjunctiva. Tear collection was accomplished by using a polyester fiber rod wick. This wick will be placed in contact with the tear fluid at the lower cul-de-sac for a minimum time to obtain fluid without irritating the subject's eye approx. for 3 to 5 minutes. |
| Measure | Description | Time Frame |
|---|---|---|
| lacritin levels in human tears | 2 minutes after instilling anesthetic eyedrop |
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Inclusion Criteria:
Exclusion Criteria:
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Military health care beneficiary between the ages of 21-55.
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| Name | Affiliation | Role |
|---|---|---|
| Kraig S. Bower, MD | WRAMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Walter Reed Army Medical Center | Washington D.C. | District of Columbia | 20307 | United States |
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