Interaction Between ABT-335, Rosuvastatin and Warfarin

Multiple-Dose Pharmacokinetic and Pharmacodynamic Interaction Between ABT-335, Rosuvastatin and Warfarin

This is a multiple-dose, double-blind, randomized, single-center, parallel-group study in adult male subjects in general good health.

Inclusion Criteria:

• Body mass index (BMI) is 19 to 29, inclusive.
• A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead electrocardiogram (ECG).
• Written informed consent prior to the initiation of screening or study-specific procedures.

Exclusion Criteria:

• Subjects with unstable medical conditions or medical conditions considered inappropriate in a clinical trial.
• Subjects taking concomitant medications.
• Subjects with a recent history of surgery or trauma.
• Subjects with a history of any bleeding disorder.