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| ID | Type | Description | Link |
|---|---|---|---|
| EudraCt nr 2007-004756-37 |
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The purpose of the study is to evaluate if AZD3480 and warfarin interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | AZD3480 + warfarin |
|
| 2 | Experimental | Placebo+ warfarin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AZD3480 | Drug | AZD3480 capsules qd, 12 days |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| PK variables | Frequent sampling occasions during days 5 and 6 |
| Measure | Description | Time Frame |
|---|---|---|
| Safety variables (adverse events, blood pressure, pulse, safety lab) | During the whole treatment period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hans-Göran Hårdemark, MD | Clinical Neuroscience TA AstraZeneca R&D Södertälje, Sweden | Study Director |
| Cyril Clarke, MD | ICON Development Solutions Manchester, UK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research SIte | Uppsala | Sweden |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| C490152 | ispronicline |
| D014859 | Warfarin |
| ID | Term |
|---|---|
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 |
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| Drug |
Placebo capsules qd, 12 days |
|
| Warfarin | Drug | Warfarin: single dose on day 6 |
|
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |