The purpose of this study is to determine whether AZD1656 will affect the Pharmacokinetics and Pharmacodynamics of Warfarin in T2DM patients.

Inclusion Criteria:

• Clinical diagnosis of T2DM treated with at least 1000 mg metformin as a single treatment or in combination with one other oral anti-diabetics for at least 2 months prior to screening. Doses of anti-diabetic treatment stable for at least 1 month
• Fasting plasma glucose (FPG) at screening in the range of 6.0 to 15.0 mmol/L (108 to 270 mg/dL) and FPG in the range of 7.5 to 13.0 mmol/L (135 to 234 mg/dL) on Day 1
• Haemoglobin (Hb) A1c >6.5% at screening

Exclusion Criteria:

• Use of drugs with anticoagulant effects 3 weeks prior to first warfarin dosing
• Use of amiodarone within 3 months prior to screening and the use of potent CYP450 inhibitors
• Previous treatment with warfarin on clinical indication