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The purpose of this study is to evaluate the safety and compare the pharmacokinetic parameters from the fixed dose combination ABT-143 relative to that from the co-administration of the two monotherapies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| A | Experimental | ABT-143 capsules 5/45mg |
|
| B | Active Comparator | ABT-335 45mg and rosuvastatin 5mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ABT-143 | Drug | Once, please see Arm Description for more details. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To determine the safety and tolerability of ABT-143 (vs. ABT-335 + rosuvastatin) in healthy adults. | 7 days | |
| To determine the pharmacokinetic profile for ABT-143 (vs. ABT-335 + rosuvastatin) in healthy adults. | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Torbjörn Lundström, MD | AstraZeneca | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Site Reference ID/Investigator# 13441 | Orlando | Florida | 32809 | United States |
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| ABT-335 |
| Drug |
Once, see Arm Description for more detail |
|
| rosuvastatin | Drug | once, see Arm Description for more detail |
|
| ID | Term |
|---|---|
| C533234 | 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid |
| D000068718 | Rosuvastatin Calcium |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D005464 | Fluorobenzenes |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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