To study different doses of MK0493 for safety, efficacy and tolerability in obese patients.

Inclusion Criteria:

• Patient is between 21 and 65 years of age

Exclusion Criteria:

• HIV positive as determined by medical history
• Patient is pregnant, lactating or plans to become pregnant
• Patient has undergone surgical treatment for obesity
• Patient has undergone a surgical procedure within 4 weeks prior to Visit 1 or plans to undergo a surgical procedure during the study
• Patient plans to consume more than 2 glasses of grapefruit juice per day during the study
• Patient has participated in another clinical study (involving an investigational drug) within 3 months prior to restudy screening