A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

A Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MK-4082 in Healthy Overweight/Obese Participants

Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies.

The goals of this study are to learn about:

• The safety of MK-4082 and if people tolerate it
• What happens to different MK-4082 dose levels in a person's body over time

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

• Is in good health
• Has body mass index (BMI) between 25 and 40 kg/m^2, inclusive. Participants must weigh at least 60 kg

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

• has a history of previous surgical treatment for obesity (bariatric surgery, gastric banding, etc.) or any other gastrointestinal (GI) surgery that may induce malabsorption, history of bowel resection >20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss (including LAP-BAND®), as well as clinically significant GI disorders (eg, peptic ulcers, severe gastroesophageal reflux disease)
• has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2