To assess the effect of MK0493 on body weight, blood pressure, mood, and appetite.

Inclusion Criteria:

• Patient is between 21 and 65 years
• Patient is able to read and understand and complete study questionnaires
• Patient is not pregnant or breast-feeding and does not plan to become pregnant for the duration of the study and post-study follow-up period

Exclusion Criteria:

• Patient has a history of significant psychiatric disorder (such as major depression, bipolar disorder, bulimia, or anorexia nervosa
• Patient is HIV positive as determined by medical history
• Patient has undergone surgical treatment for obesity
• Patient plans to consume more than two 8 ounce glasses of grapefruit juice per day during the study
• Patient participated in another clinical study involving an investigational drug) within 3 months prior to Visit 1
• Patient is currently a heavy consumer of alcohol (>2 drinks per day or >14 drinks per week [1 drink is defined as 2 oz hard alcohol, 5 oz wine, 12 oz beer], or uses (including recreational use) any illicit drugs, or has a history of drug or alcohol abuse