Study the effect of rofecoxib 50 mg compared to both placebo, and hydrocodone 7.5 mg with acetaminophen 750 mg, to treat moderate to severe pain following arthroscopic knee surgery.

Inclusion Criteria:

• Elective outpatient arthroscopic knee surgery expected to last <= 90 minutes using general anesthesia
• Patients must experience moderate to severe pain following surgery
• Patient must be in general good health as judged by the primary investigator

Exclusion Criteria:

• Osteoarthritis; rheumatoid arthritis
• Allergy/sensitivity to aspirin, ibuprofen, indomethacin, other NSAIDs, COX-2 inhibitors (e.g., rofecoxib, celecoxib), hydrocodone, acetaminophen
• Asthma associated with nasal polyps
• Any arthroscopic knee surgery in the past 6 months