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| ID | Type | Description | Link |
|---|---|---|---|
| 2004_068 |
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The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
The duration of treatment is 24 hours.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0966, rofecoxib | Drug | |||
| Comparator: oxycodone with acetaminophen, placebo | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Post-op dental pain over 6 hours as measured by pain intensity/relief scores, patient global assessment, and time to perceptible/meaningful pain relief. |
| Measure | Description | Time Frame |
|---|---|---|
| Time to onset of analgesic effect, peak analgesic effect, and/or duration of analgesic effect over 24 hours. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17656293 | Background | Desjardins PJ, Black PM, Daniels SE, Bird SR, Petruschke RA, Chang DJ, Smugar SS, Tershakovec AM. A double-blind randomized controlled trial of rofecoxib and multidose oxycodone/acetaminophen in dental impaction pain. J Oral Maxillofac Surg. 2007 Aug;65(8):1624-32. doi: 10.1016/j.joms.2006.06.268. No abstract available. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| C116926 | rofecoxib |
| D000082 | Acetaminophen |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| Aniline Compounds |
| D000588 | Amines |