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| ID | Type | Description | Link |
|---|---|---|---|
| 2004_069 |
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The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
The duration of treatment is 1 day.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK0966, rofecoxib | Drug | |||
| Comparator: valdecoxib, placebo | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Overall analgesic effect as measured by total pain relief over 12 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Overall analgesic effect over 8 hrs. | ||
| Time to onset of analgesic, peak analgesic and duration of analgesic effects. | ||
| Percent of patients using and amount used of supplemental analgesia within 8, 12, and 24 hrs. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16990080 | Background | Daniels SE, Desjardins PJ, Bird SR, Smugar SS, Tershakovec AM. Rofecoxib 50 mg and valdecoxib 20 or 40 mg in adults and adolescents with postoperative pain after third molar extraction: results of two randomized, double-blind, placebo-controlled, single-dose studies. Clin Ther. 2006 Jul;28(7):1022-34. doi: 10.1016/j.clinthera.2006.07.005. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| CSR Synopsis | View IPD |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| C116926 | rofecoxib |
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| Overall safety and tolerability. |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |