Lumigan Versus Cosopt

To compare the intraocular pressure effect and safety of the dorzolamide/timolol fixed combination given twice daily versus bimatoprost given once every evening in patients with open-angle glaucoma in patients insufficiently controlled on latanoprost monotherapy

Inclusion Criteria:

• adults with a diagnosis of bilateral open-angle glaucoma including: primary, pigment dispersion or exfoliation in both eyes
• on no therapy the intraocular pressure should be 22-29 mm Hg inclusive at the 8:00 AM measurement
• visual acuity should be 20/200 or better in each eye

Exclusion Criteria:

• historical failure to respond to topical beta-blockers in a clinically meaningful manner
• any contraindication to study medications
• any anticipated change, or modification in the 6 weeks prior to Visit 1, in systemic hypertensive therapy during the trial